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Study · Measured the body's own peptide · 2025

3 results

The effect of MDMA administration on oxytocin concentration levels: systematic review and a multilevel meta-analysis in humans.

Vaslavski A, Gross AH, Israel S, Peled-Avron L

Neuroscience and biobehavioral reviews12 Aug 2025

PMID40812728 (opens in a new tab)DOI10.1016/j.neubiorev.2025.106324 (opens in a new tab)PepBankPUB-40812728
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelSystematic reviewMechanism

    In humans given MDMA, peripheral oxytocin levels rose over time and peaked between 150 and 200 min before declining.

    In plain wordsIn people given MDMA, the body's own oxytocin rose and peaked between 150 and 200 minutes, then fell.

    Peptide
    Oxytocin
    Outcome
    IncreasePeripheral oxytocin level over time after MDMA
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Measurements

    Time of peak oxytocin
    150 to 200 min
    after MDMA

    Source sentences

    Summary
    Results revealed that oxytocin levels increased over time, peaking between 150 and 200 min, before declining.
    2 context sentences
    Summary · context
    A systematic search identified ten studies, comprising 39 effect size estimates.
    Summary · context
    Multilevel meta-analyses were conducted using Hedge's g as the primary outcome, with dose, time of measurement, and sex as moderators.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelSystematic reviewMechanism

    In the meta-analysis of MDMA studies, MDMA dose did not significantly predict the change in peripheral oxytocin.

    In plain wordsIn people given MDMA, the dose did not clearly predict how much the body's own oxytocin changed.

    Peptide
    Oxytocin
    Outcome
    No significant changeMDMA dose as moderator of oxytocin change
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    The dose did not significantly predict oxytocin changes
    2 context sentences
    Summary · context
    A systematic search identified ten studies, comprising 39 effect size estimates.
    Summary · context
    Multilevel meta-analyses were conducted using Hedge's g as the primary outcome, with dose, time of measurement, and sex as moderators.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelSystematic reviewMechanism

    A trend suggested smaller oxytocin increases after MDMA in samples with a higher proportion of female participants.

    In plain wordsA trend showed smaller rises in the body's own oxytocin after MDMA in samples with more women.

    Peptide
    Oxytocin
    Outcome
    DecreaseSex as moderator of oxytocin increase after MDMA
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    a trend suggested that samples with a higher proportion of female participants exhibited smaller increases in oxytocin levels.
    2 context sentences
    Summary · context
    A systematic search identified ten studies, comprising 39 effect size estimates.
    Summary · context
    Multilevel meta-analyses were conducted using Hedge's g as the primary outcome, with dose, time of measurement, and sex as moderators.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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