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Study · Animal study (in vivo) · rat · 2025

16 results

The Effect of Abaloparatide on New Bone Formation in Critical Calvarial Defectsin a Postmenopausal Model.

Özdoğan Z, Kizildağ A, Özmen Ö

The Journal of craniofacial surgery6 Aug 2025

PMID40769144 (opens in a new tab)DOI10.1097/scs.0000000000011777 (opens in a new tab)PepBankPUB-40769144
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats with calvarial defects, local abaloparatide alone improved bone healing versus control.

    In plain wordsIn rats with calvarial defects, local abaloparatide alone improved bone healing compared with control.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseBone healing
    Study

    ratn = 16

    ovariectomized rats with critical calvarial defects
    Comparator
    control
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · localAs given in this study (rat).

    Source sentences

    Summary
    Significant improvements were found in bone healing in the ABL and O groups, compared with the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

Studies that did not test the peptide alone15

In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Abaloparatide (Tymlos).

  1. 02AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft produced the highest total healing area among study groups.

    In plain wordsIn rats, abaloparatide plus autogenous graft produced the highest total healing area among study groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseTotal healing area
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The ABL+O group reached the highest values in terms of total healing area, defect closure rate, and new bone formation.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  2. 03AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft produced the highest defect closure rate among study groups.

    In plain wordsIn rats, abaloparatide plus autogenous graft produced the highest defect closure rate among study groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseDefect closure rate
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The ABL+O group reached the highest values in terms of total healing area, defect closure rate, and new bone formation.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  3. 04AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft produced the highest new bone formation among study groups.

    In plain wordsIn rats, abaloparatide plus autogenous graft produced the highest new bone formation among study groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseNew bone formation
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The ABL+O group reached the highest values in terms of total healing area, defect closure rate, and new bone formation.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  4. 05AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft produced the most osteoblasts among study groups.

    In plain wordsIn rats, abaloparatide plus autogenous graft produced the most bone-forming cells among study groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOsteoblast number
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Histopathologic analysis showed that the ABL+O group had the most osteoblasts and the fewest osteoclasts.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  5. 06AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft produced the fewest osteoclasts among study groups.

    In plain wordsIn rats, abaloparatide plus autogenous graft produced the fewest bone-resorbing cells among study groups.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseOsteoclast number
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Histopathologic analysis showed that the ABL+O group had the most osteoblasts and the fewest osteoclasts.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  6. 07AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, abaloparatide plus autogenous graft had the best reported micro-CT results for bone density, trabecular thickness and number.

    In plain wordsIn rats, abaloparatide plus autogenous graft had the best reported micro-CT bone architecture results.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    Direction not reportedMicro-CT bone architecture
    Study

    ratn = 32

    ovariectomized rats with critical calvarial defects
    Comparator
    other study groups
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Micro-CT analysis showed that the ABL+O group had the best results in terms of bone density, trabecular thickness, and trabecular number.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  7. 08AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, collagen-1 expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, collagen-1 expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseCollagen-1 expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  8. 09AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, osteocalcin expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, osteocalcin expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOsteocalcin expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  9. 10AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, osteonectin expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, osteonectin expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOsteonectin expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  10. 11AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, OST expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, OST expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOST expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  11. 12AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, OPG expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, OPG expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseOPG expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  12. 13AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, RUNX2 expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, RUNX2 expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseRUNX2 expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  13. 14AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, TGF-β expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, TGF-β expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseTGF-β expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  14. 15AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Efficacy outcome

    In ovariectomized rat defects, VEGF expression increased in the abaloparatide plus autogenous graft group.

    In plain wordsIn rats, VEGF expression increased with abaloparatide plus autogenous graft.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseVEGF expression
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    3 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.
    Summary · context
    After 8 weeks, rats were sacrificed and bone regeneration was evaluated using microCT and histologic analyses.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

  15. 16AnimalNot a test of Abaloparatide (Tymlos) aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats with calvarial defects, RANKL expression was lower with abaloparatide plus autogenous graft than in controls, which had the highest expression.

    In plain wordsIn rats with calvarial defects, RANKL expression was lower with abaloparatide plus autogenous graft than in controls.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseRANKL expression relative to control
    Study

    ratn: not reported in source

    ovariectomized rats with critical calvarial defects
    Comparator
    control
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    Collagen-1, osteocalcin, osteonectin, OST, OPG, RUNX2, TGF-β, and VEGF expressions were increased in the ABL+O group, and RANKL expression was highest in the C group.
    2 context sentences
    Summary · context
    We examined the effect of locally administered abaloparatide (ABL), alone or combined with an autogenous graft, on new bone formation in critical-sized calvarial defects in postmenopausal rats.
    Summary · context
    Thirty-two ovariectomized rats were divided into 4 equal groups: control (C), ABL, autogenous (O), and ABL+O.

    In this study, Abaloparatide (Tymlos) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Abaloparatide (Tymlos).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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