The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and rats.

Kuhre RE, Ballarín-González B, Brand CL, Glendorf T, Madsen KG, Hjøllund KR, Hogendorf WFJ, Ipsen DH, Lundh S, Kruse T, Petersen SB, Secher A, Vegge A, Raun K

EBioMedicine23 Jul 2025Cited by 13 (Europe PMC)

PMID40706446PMCIDPMC12309853DOI10.1016/j.ebiom.2025.105862PepBankPUB-40706446

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Summary

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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diet-induced obese rats, amycretin reduced total energy intake by 47% compared with vehicle.
In plain wordsIn rats with diet-induced obesity, amycretin reduced energy intake compared with vehicle.
Peptide
Amycretin
Outcome
DecreaseEnergy intake
Study
ratn: not reported in source
diet-induced obesity
Comparator
vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · 21 daysAs given in this study (rat).
Source sentences
Summary
In diet-induced obese (DIO) rats, amycretin administration for 21 days reduced total energy intake by 47% (95% CI (mean), kcal: vehicle: 2132-2493 vs. amycretin: 1044-1390)
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644604
02AnimalAnimal study (in vivo)Efficacy outcome
In diet-induced obese rats, amycretin lowered body weight by 18% compared with vehicle.
In plain wordsIn rats with diet-induced obesity, amycretin lowered body weight compared with vehicle.
Peptide
Amycretin
Outcome
DecreaseBody weight
Study
ratn: not reported in source
diet-induced obesity
Comparator
vehicle
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · 21 daysAs given in this study (rat).
Source sentences
Summary
and lowered body weight by 18% (95% CI (mean), % change relative to pre-treatment: vehicle: 6.56-8.47 vs. amycretin: -10.48 to -12.74, p < 0.0001)
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644605
03AnimalAnimal study (in vivo)Efficacy outcome
In diet-induced obese rats, amycretin maintained energy expenditure.
In plain wordsIn rats with diet-induced obesity, amycretin maintained energy expenditure.
Peptide
Amycretin
Outcome
Not applicableEnergy expenditure
Study
ratn: not reported in source
diet-induced obesity
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · 21 daysAs given in this study (rat).
Source sentences
Summary
while maintaining energy expenditure.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644606
04AnimalAnimal study (in vivo)Mechanism
In mice, amycretin targeted brain areas that regulate food intake.
In plain wordsIn mice, amycretin reached brain areas that control food intake.
Peptide
Amycretin
Outcome
Not applicableBrain access
Study
mousen: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Amycretin targeted key areas of the mouse brain that regulate food intake.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644607
05AnimalAnimal study (in vivo)Efficacy outcome
In diet-induced obese rats, amycretin improved insulin sensitivity versus vehicle, with higher clamp glucose infusion rates.
In plain wordsIn rats with diet-induced obesity, amycretin improved insulin sensitivity compared with vehicle.
Peptide
Amycretin
Outcome
IncreaseInsulin sensitivity
Study
ratn: not reported in source
diet-induced obesity
Comparator
vehicle
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
Insulin sensitivity improved significantly with amycretin administration in DIO rats compared with vehicle controls, shown by higher glucose infusion rates during a hyperinsulinaemic euglycemic clamp.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644608
06AnimalAnimal study (in vivo)Efficacy outcome
In rodent studies, amycretin improved histological MASLD hallmarks, primarily through reduced steatosis.
In plain wordsIn rodents, amycretin improved fatty-liver features, mainly through reduced liver fat.
Peptide
Amycretin
Outcome
DecreaseHepatic steatosis
Study
n: not reported in source
MASLD
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Additionally, amycretin improved histological hallmarks of MASLD, primarily by reducing steatosis.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644609
07LabIn vitro (cells)Activity measurement
In cell-based systems, amycretin activated human, mouse and rat GLP-1 receptors.
In plain wordsIn cells, amycretin activated human, mouse and rat GLP-1 receptors.
Peptide
Amycretin
Outcome
IncreaseGLP-1 receptor activation
Study
human, mouse and ratn: not reported in source
cell-based receptor systems
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Amycretin activated human, mouse and rat GLP-1, amylin and calcitonin receptors in cell-based systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644601
08LabIn vitro (cells)Activity measurement
In cell-based systems, amycretin activated human, mouse and rat amylin receptors.
In plain wordsIn cells, amycretin activated human, mouse and rat amylin receptors.
Peptide
Amycretin
Outcome
IncreaseAmylin receptor activation
Study
human, mouse and ratn: not reported in source
cell-based receptor systems
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Amycretin activated human, mouse and rat GLP-1, amylin and calcitonin receptors in cell-based systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644602
09LabIn vitro (cells)Activity measurement
In cell-based systems, amycretin activated human, mouse and rat calcitonin receptors.
In plain wordsIn cells, amycretin activated human, mouse and rat calcitonin receptors.
Peptide
Amycretin
Outcome
IncreaseCalcitonin receptor activation
Study
human, mouse and ratn: not reported in source
cell-based receptor systems
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
Dose not stated
Source sentences
Summary
Amycretin activated human, mouse and rat GLP-1, amylin and calcitonin receptors in cell-based systems.
1 context sentence(design, population, supporting numbers)
Summary · context
Preclinical studies were conducted to characterise amycretin activation of GLP-1, amylin and calcitonin receptors, and determine the effects of amycretin administration on the metabolic health of mice and rats.
Report a problemFND-4070644603

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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