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Study · Not a test of the peptide alone · 2025

3 results

A single injection of a long-acting oxytocin analog (carbetocin) at estrus onset synchronizes ovulations and enhances ovulation rate in ewes.

Jp B, Mgk R, Jdr S, Mi V, M R, R U

Theriogenology18 Jul 2025

PMID40694878 (opens in a new tab)DOI10.1016/j.theriogenology.2025.117600 (opens in a new tab)PepBankPUB-40694878
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In ewes, a single intravenous dose of the oxytocin analog carbetocin at estrus onset increased the ovulation rate versus control.

    In plain wordsIn ewes, one injection of carbetocin, an oxytocin-like drug, raised the ovulation rate compared with untreated ewes.

    Peptide
    Oxytocin
    Outcome
    IncreaseOvulation rate
    Study

    sheep (Merilin ewes)n = 20

    Comparator
    Control (untreated ewes)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    ovulation rate
    1.9
    carbetocin
    ovulation rate
    1.4
    control

    Source sentences

    Summary
    Carbetocin treatment increased the ovulation rate (1.9 ± 0.2 and 1.4 ± 0.2; P = 0.04)
    1 context sentence
    Summary · context
    Upon detection of estrus, ewes were randomly assigned to a control (CON, n = 10) or Carbetocin-treated (CAR, n = 10) group.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In ewes, the oxytocin analog carbetocin reduced the spread in the interval between end of estrus and ovulation versus control.

    In plain wordsIn ewes, carbetocin, an oxytocin-like drug, made the timing of ovulation more uniform than in untreated ewes.

    Peptide
    Oxytocin
    Outcome
    DecreaseDispersion of interval between end of estrus and ovulation
    Study

    sheep (Merilin ewes)n = 20

    Comparator
    Control (untreated ewes)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    SD of interval
    3.86
    carbetocin
    SD of interval
    8.01
    control

    Source sentences

    Summary
    reduced the dispersion in interval between the end of estrus and time of ovulation (SD: 3.86 and 8.01, respectively, P = 0.04).
    1 context sentence
    Summary · context
    Upon detection of estrus, ewes were randomly assigned to a control (CON, n = 10) or Carbetocin-treated (CAR, n = 10) group.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In ewes, the oxytocin analog carbetocin did not shorten duration of estrus compared with ewes with multiple matings.

    In plain wordsIn ewes, carbetocin, an oxytocin-like drug, did not shorten estrus compared with ewes that mated several times.

    Peptide
    Oxytocin
    Outcome
    No significant changeDuration of estrus
    Study

    sheep (Merilin ewes)n = 20

    Comparator
    Ewes with multiple matings
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    but compared with ewes where there were multiple matings, did not shorten duration of estrus.
    1 context sentence
    Summary · context
    Upon detection of estrus, ewes were randomly assigned to a control (CON, n = 10) or Carbetocin-treated (CAR, n = 10) group.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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