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Study · Animal study (in vivo) · mouse · 2025

8 results

Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.

Liu R, Chen Y, Huang H, Li X, Lv J, Jiang L, Jiang H, Wu C, Chen W, Xu H, Zhu Z, Cai H, Xiao J, Yin L, Ni W

British journal of pharmacology21 Jul 2025

PMID40692165 (opens in a new tab)DOI10.1111/bph.70122 (opens in a new tab)PepBankPUB-40692165
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice with spinal cord injury, Semax improved functional recovery.

    In plain wordsIn mice with spinal cord injury, Semax improved recovery of movement function.

    Peptide
    Semax
    Outcome
    IncreaseFunctional recovery after spinal cord injury
    Study

    mousen: not reported in source

    spinal cord injury (T9-T10 impact), female C57BL/6 mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax improved SCI functional recovery
    1 context sentence
    Summary · context
    An SCI mouse model was generated by impacting the spinal cord of female C57BL/6 mice at T9-T10.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, Semax inhibited lysosomal membrane permeabilization-related pyroptosis.

    In plain wordsIn mice with spinal cord injury, Semax reduced a form of inflammatory cell death.

    Peptide
    Semax
    Outcome
    DecreaseLMP-related pyroptosis in SCI mice
    Study

    mousen: not reported in source

    spinal cord injury (T9-T10 impact), female C57BL/6 mice
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited LMP-related pyroptosis in SCI mice
    1 context sentence
    Summary · context
    An SCI mouse model was generated by impacting the spinal cord of female C57BL/6 mice at T9-T10.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with spinal cord injury, Semax decreased oxidative stress.

    In plain wordsIn mice with spinal cord injury, Semax lowered oxidative stress.

    Peptide
    Semax
    Outcome
    DecreaseOxidative stress in SCI mice
    Study

    mousen: not reported in source

    spinal cord injury (T9-T10 impact), female C57BL/6 mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    by decreasing oxidative stress.
    1 context sentence
    Summary · context
    An SCI mouse model was generated by impacting the spinal cord of female C57BL/6 mice at T9-T10.
  4. 04AnimalAnimal study (in vivo)Mechanism

    RNA sequencing and other analyses found that Semax regulated the ubiquitin specific protease USP18.

    In plain wordsIn the study's analyses, Semax was found to regulate the enzyme USP18.

    Peptide
    Semax
    Outcome
    Direction not reportedUSP18 regulation by Semax
    Study

    mousen: not reported in source

    spinal cord injury (T9-T10 impact), female C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RNA-seq and other analyses found that Semax regulated the ubiquitin specific protease USP18.
    1 context sentence
    Summary · context
    An SCI mouse model was generated by impacting the spinal cord of female C57BL/6 mice at T9-T10.
  5. 05AnimalAnimal study (in vivo)Mechanism

    USP18 knockdown confirmed the role of Semax in spinal cord injury recovery.

    In plain wordsIn mice, reducing USP18 confirmed that this enzyme is part of how Semax helps recovery after spinal cord injury.

    Peptide
    Semax
    Outcome
    Not applicableUSP18 knockdown and SCI recovery
    Study

    mousen: not reported in source

    spinal cord injury (T9-T10 impact), female C57BL/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    USP18 knockdown confirmed Semax's role in SCI recovery.
    1 context sentence
    Summary · context
    An SCI mouse model was generated by impacting the spinal cord of female C57BL/6 mice at T9-T10.
  6. 06LabIn vitro (cells)Mechanism

    In a PC12 cell neuroinflammation model, Semax inhibited lysosomal membrane permeabilization-related pyroptosis.

    In plain wordsIn cells, Semax reduced a form of inflammatory cell death in a neuroinflammation model.

    Peptide
    Semax
    Outcome
    DecreaseLMP-related pyroptosis in neuroinflammation cell model
    Study

    n: not reported in source

    PC12 cell neuroinflammation model
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited LMP-related pyroptosis in SCI mice and neuroinflammation models
    1 context sentence
    Summary · context
    the PC12 cell neuroinflammation model were analysed using immunofluorescence, Western blot, RT-qPCR and transmission electron microscopy.
  7. 07LabIn vitro (cells)Mechanism

    In a PC12 cell neuroinflammation model, Semax decreased oxidative stress.

    In plain wordsIn cells, Semax lowered oxidative stress in a neuroinflammation model.

    Peptide
    Semax
    Outcome
    DecreaseOxidative stress in neuroinflammation cell model
    Study

    n: not reported in source

    PC12 cell neuroinflammation model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    neuroinflammation models, by decreasing oxidative stress.
    1 context sentence
    Summary · context
    the PC12 cell neuroinflammation model were analysed using immunofluorescence, Western blot, RT-qPCR and transmission electron microscopy.
  8. 08Computer modelIn silicoMechanism

    Network pharmacology and molecular docking identified the mu-opioid receptor as a target of Semax.

    In plain wordsIn computer predictions, the mu-opioid receptor was identified as a likely target of Semax.

    Peptide
    Semax
    Outcome
    Not applicableMu-opioid receptor as predicted Semax target
    Study

    n: not reported in source

    network pharmacology and molecular docking
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Network pharmacology and docking revealed the μ-opioid receptor as a Semax target.
    1 context sentence
    Summary · context
    network pharmacology and molecular docking were used to identify possible molecular targets of Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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