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Study · Measured the body's own peptide · 2025

2 results

Repeated Heat Stress Modulates the Levels of the Mitokines MOTS-C and FGF21 in Active Men during Calf Muscle Immobilization.

Elhusseiny R, Ihsan M, Labidi M, Alhammoud M, Mtibaa K, Nader N, Nasir N, Farooq A, Papakostas E, Olory B, Cruz F, D'Hooghe P, Racinais S, Deldicque L

Medicine and science in sports and exercise17 Jul 2025Cited by 1 (Europe PMC)

PMID40674654 (opens in a new tab)DOI10.1249/mss.0000000000003825 (opens in a new tab)PepBankPUB-40674654
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In active men with calf immobilization, repeated heat treatment upregulated circulating MOTS‑c compared with sham treatment.

    In plain wordsIn active men with an immobilized ankle, repeated heat raised the body's own MOTS‑c in the blood compared with sham treatment.

    Peptide
    MOTS-c
    Outcome
    IncreaseCirculating MOTS-c after repeated heat treatment
    Study

    n = 19

    Comparator
    Sham treatment
    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    repeated heat treatment upregulated the circulating MOTS-c ( P = 0.033)
    1 context sentence
    Summary · context
    A total of 19 physically active men underwent 4 wk of supervised training followed by 2 wk of immobilization of the left ankle, during which they were randomly divided into the heat ( n = 9) or the sham ( n = 10) treatment group.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In active men, 2 weeks of calf immobilization did not change levels of the body's own MOTS‑c.

    In plain wordsIn active men, wearing an ankle immobilizer did not change the body's own MOTS‑c levels.

    Peptide
    MOTS-c
    Outcome
    No significant changeMitokine levels after immobilization
    Study

    n = 19

    Outcome group
    Mitochondrial function · Musculoskeletal

    Source sentences

    Summary
    Although immobilization did not induce any effect on mitokine levels
    1 context sentence
    Summary · context
    A total of 19 physically active men underwent 4 wk of supervised training followed by 2 wk of immobilization of the left ankle, during which they were randomly divided into the heat ( n = 9) or the sham ( n = 10) treatment group.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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