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Study · Animal study (in vivo) · mouse · 2025

8 results

Effects of cerebrolysin on behavioral changes and the tryptophan-kynurenine pathway in the prefrontal cortex of male mice in the ketamine model of schizophrenia.

Mafikandi V, Hosseini L, Seyedaghamiri F, Mansourian H, Shahabi P, Taghizadeh S, Fakhari A

Molecular biology reports16 Jul 2025

PMID40668305 (opens in a new tab)DOI10.1007/s11033-025-10820-9 (opens in a new tab)PepBankPUB-40668305
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ketamine-treated mice, Cerebrolysin reduced anxiety-like behavior versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin reduced anxiety-like behavior versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAnxiety-like behavior
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that CBL administration significantly reduced anxiety-like behaviors, improved locomotor activity, decreased immobility time, and enhanced spatial learning and memory.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ketamine-treated mice, Cerebrolysin improved locomotor activity versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin improved movement versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseLocomotor activity
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that CBL administration significantly reduced anxiety-like behaviors, improved locomotor activity, decreased immobility time, and enhanced spatial learning and memory.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ketamine-treated mice, Cerebrolysin reduced immobility time versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin reduced time without movement versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseImmobility time
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that CBL administration significantly reduced anxiety-like behaviors, improved locomotor activity, decreased immobility time, and enhanced spatial learning and memory.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ketamine-treated mice, Cerebrolysin improved spatial learning and memory versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin improved spatial learning and memory versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpatial learning and memory
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that CBL administration significantly reduced anxiety-like behaviors, improved locomotor activity, decreased immobility time, and enhanced spatial learning and memory.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In ketamine-treated mice, Cerebrolysin lowered prefrontal KYN levels versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin lowered prefrontal KYN levels versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePrefrontal KYN levels
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, CBL significantly lowered KYN levels and increased TRP levels in the PFC.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In ketamine-treated mice, Cerebrolysin increased prefrontal TRP levels versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin increased prefrontal TRP levels versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePrefrontal TRP levels
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Furthermore, CBL significantly lowered KYN levels and increased TRP levels in the PFC.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In ketamine-treated mice, Cerebrolysin did not significantly change NLRP3 levels versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin did not significantly change NLRP3 levels versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNLRP3 levels
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    However, CBL did not significantly impact NLRP3 and IL-1β levels compared to the Ket group.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In ketamine-treated mice, Cerebrolysin did not significantly change IL-1β levels versus ketamine alone.

    In plain wordsIn mice given ketamine, Cerebrolysin did not significantly change IL-1β levels versus ketamine alone.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeIL-1β levels
    Study

    mousen: not reported in source

    Male BALB/c mice given ketamine
    Comparator
    Ketamine group
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    2.5 mL/kg per day · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    However, CBL did not significantly impact NLRP3 and IL-1β levels compared to the Ket group.
    1 context sentence
    Summary · context
    Thirty-six male BALB/c mice were allocated into three experimental groups: control, ketamine (Ket) (20 mg/kg per day, i.p.), and Ket + CBL (2.5 mL/kg per day, i.p.).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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