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Study · Not a test of the peptide alone · 2025

3 results

Efficacy of Hormonal and Non-Hormonal Vaginal Gel Preparations on the Female Sexual Satisfaction Index in Postmenopausal Women with Sexual Dysfunction Syndrome: A PRISMA-compliant meta-analysis.

Soliman A, Alrashidi H, Mohamed MA, Ghorab R, Al Riyami N, Ashour ASA, Mohammed YA, Saad AH

Sultan Qaboos University medical journal1 May 2025

PMID40641729 (opens in a new tab)PMCIDPMC12244233 (opens in a new tab)DOI10.18295/squmj.6.2024.00 (opens in a new tab)PepBankPUB-40641729
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome

    In postmenopausal women with sexual dysfunction, pooled vaginal gels (hormonal and non-hormonal) raised the total FSFI score more than placebo.

    In plain wordsIn postmenopausal women with sexual dysfunction, vaginal gels as a group improved sexual function scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseTotal FSFI score, all vaginal gels
    Study

    n = 672

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health

    Measurements

    MD
    6.67
    all vaginal gels

    Source sentences

    Summary
    The vaginal gel group had a significantly higher total FSFI endpoint score (mean difference [MD] = 6.67, 95% confidence interval [CI]: 3.79-9.55; P < 0.001) than placebo.
    1 context sentence
    Summary · context
    Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome

    In postmenopausal women with sexual dysfunction, pooled hormonal gels (oestrogen and oxytocin) raised the total FSFI score versus placebo.

    In plain wordsIn postmenopausal women, hormone gels (oestrogen and oxytocin pooled) improved sexual function scores versus placebo, less than non-hormonal gels.

    Peptide
    Oxytocin
    Outcome
    IncreaseTotal FSFI score, hormonal gels (oestrogen and oxytocin pooled)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sexual function · Reproductive and sexual health

    Measurements

    MD
    2.75
    hormonal gels

    Source sentences

    Summary
    hormonal gels (MD = 2.75, 95% CI: 1.87-3.64; P < 0.001), positively impacting all FSFI domains.
    1 context sentence
    Summary · context
    Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome

    In postmenopausal women, non-hormonal gels showed a greater FSFI gain than pooled hormonal gels (oestrogen and oxytocin).

    In plain wordsIn postmenopausal women, chamomile and fennel gels gave bigger sexual function gains than pooled hormone gels, which included oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseTotal FSFI score, non-hormonal versus hormonal gels
    Study

    n: not reported in source

    Comparator
    Hormonal gels
    Outcome group
    Sexual function · Reproductive and sexual health

    Measurements

    MD
    6.73
    non-hormonal gels
    MD
    2.75
    hormonal gels

    Source sentences

    Summary
    Non-hormonal gels exhibited a greater FSFI total score (MD = 6.73, 95% CI: 4.7-8.76; P P < 0.001), positively impacting all FSFI domains.
    1 context sentence
    Summary · context
    Searches of electronic databases from inception to January 2023 identified 8 trials (N = 672) that reported the Female Sexual Function Index (FSFI) and compared hormonal (oestrogen, oxytocin) and/or non-hormonal (chamomile, fennel) interventions against placebo.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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