Effects of Dulaglutide in Doxorubicin Induced Renal Toxicity in Rats.

Hama Said HJ, Ahmed ZA

Biologics : targets & therapy3 Jul 2025Cited by 3 (Europe PMC)

PMID40630078PMCIDPMC12235444DOI10.2147/btt.s523547PepBankPUB-40630078

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with doxorubicin kidney injury, dulaglutide lowered blood urea nitrogen versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide lowered blood urea nitrogen versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseBlood urea nitrogen
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
3 context sentences(design, population, supporting numbers)
Summary · context
the positive control group (received Distilled water and a single dose of DOX)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with doxorubicin kidney injury, dulaglutide lowered serum creatinine versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide lowered blood creatinine versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007802
03AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide lowered C-reactive protein versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide lowered C-reactive protein versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseC-reactive protein
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007803
04AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide reduced the blood neutrophil/lymphocyte ratio versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide reduced the neutrophil/lymphocyte ratio versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseNeutrophil/lymphocyte ratio
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007804
05AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide reduced the blood monocyte/lymphocyte ratio versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide reduced the monocyte/lymphocyte ratio versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseMonocyte/lymphocyte ratio
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007805
06AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide reduced renal malondialdehyde versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide reduced kidney malondialdehyde versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal malondialdehyde
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
Additionally, it resulted in a significant reduction in the renal tissue levels of MDA, IL-1β, and TNF-α, while the level of TAOC was significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007806
07AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide reduced renal interleukin-1 beta versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide reduced kidney interleukin-1 beta versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal interleukin-1 beta
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
Additionally, it resulted in a significant reduction in the renal tissue levels of MDA, IL-1β, and TNF-α, while the level of TAOC was significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007807
08AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide reduced renal TNF-alpha versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide reduced kidney TNF-alpha versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal TNF-alpha
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
Additionally, it resulted in a significant reduction in the renal tissue levels of MDA, IL-1β, and TNF-α, while the level of TAOC was significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007808
09AnimalAnimal study (in vivo)Mechanism
In rats with doxorubicin kidney injury, dulaglutide increased renal total antioxidant capacity versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, dulaglutide increased kidney antioxidant capacity versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
IncreaseRenal total antioxidant capacity
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
Additionally, it resulted in a significant reduction in the renal tissue levels of MDA, IL-1β, and TNF-α, while the level of TAOC was significantly elevated.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007809
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with doxorubicin kidney injury, histopathological assessments supported the protective findings with dulaglutide versus the positive control.
In plain wordsIn rats with doxorubicin kidney injury, tissue assessments supported protection with dulaglutide versus the positive control.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal histopathology
Study
ratn: not reported in source
Doxorubicin-induced acute kidney injury
Comparator
Doxorubicin plus distilled water
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated · intraperitoneal · 14 daysAs given in this study (rat).
Source sentences
Summary
These findings were supported by histopathological assessments.
3 context sentences(design, population, supporting numbers)
Summary · context
DUL significantly lowered the levels of BUN, SCr, and CRP, and reduced the levels of blood inflammation markers, including NLR and MLR.
Summary · context
Twenty-eight male rats were randomly allocated into four groups:
Summary · context
All DOX doses (20 mg/kg) were given at day 13th of the study and all treatments were administered intraperitoneally for 14 days.
Report a problemFND-4063007810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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