Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery.

Wang Z, Zhang L, Wang B, Wang M, Zhang J

Journal of materials chemistry. B30 Jul 2025

PMID40626902DOI10.1039/d5tb00580aPepBankPUB-40626902

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

01HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical subjects, BMa/AHP-8 cream reduced wrinkle number more than AHP-8 monotherapy after 28 days.
In plain wordsIn clinical subjects, the combination cream reduced wrinkle number more than AHP-8 alone after 28 days.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseWrinkle number
Study
n: not reported in source
Comparator
AHP-8 alone
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Clinical trials indicated that the subjects using the BMa/AHP-8 facial cream experienced a greater reduction in wrinkle number, length, and area after 28 days than those using AHP-8 monotherapy.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690205
02HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical subjects, BMa/AHP-8 cream reduced wrinkle length more than AHP-8 monotherapy after 28 days.
In plain wordsIn clinical subjects, the combination cream reduced wrinkle length more than AHP-8 alone after 28 days.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseWrinkle length
Study
n: not reported in source
Comparator
AHP-8 alone
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Clinical trials indicated that the subjects using the BMa/AHP-8 facial cream experienced a greater reduction in wrinkle number, length, and area after 28 days than those using AHP-8 monotherapy.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690206
03HumanNot a test of Argireline (acetyl hexapeptide-8) aloneNon-randomized trialEfficacy outcome
In clinical subjects, BMa/AHP-8 cream reduced wrinkle area more than AHP-8 monotherapy after 28 days.
In plain wordsIn clinical subjects, the combination cream reduced wrinkle area more than AHP-8 alone after 28 days.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseWrinkle area
Study
n: not reported in source
Comparator
AHP-8 alone
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Clinical trials indicated that the subjects using the BMa/AHP-8 facial cream experienced a greater reduction in wrinkle number, length, and area after 28 days than those using AHP-8 monotherapy.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690207
04LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Efficacy outcome
In cellular assays, BMa/AHP-8 increased collagen I production through regulation of the TGF-β pathway.
In plain wordsIn cells, the BMa/AHP-8 mixture increased collagen I production.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseCollagen I production
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Cellular assays demonstrated that BMa/AHP-8 significantly increased collagen I production by regulating the TGF-β pathway and inhibited acetylcholine release more effectively than AHP-8 alone.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690203
05LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Efficacy outcome
In cellular assays, BMa/AHP-8 inhibited acetylcholine release more than AHP-8 alone.
In plain wordsIn cells, the BMa/AHP-8 mixture reduced acetylcholine release more than AHP-8 alone.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseAcetylcholine release
Study
n: not reported in source
Comparator
AHP-8 alone
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Cellular assays demonstrated that BMa/AHP-8 significantly increased collagen I production by regulating the TGF-β pathway and inhibited acetylcholine release more effectively than AHP-8 alone.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690204
06LabNot a test of Argireline (acetyl hexapeptide-8) aloneOther designActivity measurement
In transdermal tests, BMa/AHP-8 produced greater AHP-8 cumulative permeation than free AHP-8.
In plain wordsIn lab tests, the BMa/AHP-8 system increased peptide passage compared with free AHP-8.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseCumulative permeation at 24 h
Study
n: not reported in source
in vitro transdermal model
Comparator
AHP-8 alone
Outcome group
Skin and hair · Skin and wound
Measurements
Relative cumulative permeation
3.1 fold
BMa/AHP-8 versus free AHP-8 at 24 h
Source sentences
Summary
In vitro transdermal studies showed that the 24-h cumulative permeation of AHP-8 in BMa/AHP-8 was 3.10 times that of free AHP-8.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690201
07Computer modelNot a test of Argireline (acetyl hexapeptide-8) aloneIn silicoMechanism
In molecular dynamics simulations, BMa reduced the free energy barrier for AHP-8 permeation through cation-lipid interactions.
In plain wordsComputer simulations indicated that BMa reduced the energy barrier for AHP-8 passage.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreasePermeation free energy barrier
Study
n: not reported in source
molecular dynamics simulation
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Molecular dynamics simulations revealed that BMa reduces the free energy barrier for AHP-8 permeation mainly due to the interactions between cations and the lipid matrix.
1 context sentence(design, population, supporting numbers)
Summary · context
This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4062690202

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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