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Study · Randomized controlled trial · n = 50 · 2025

4 results

Intranasal oxytocin increases cooperation of heterosexual men with women.

Cosme G, Patrocínio M, Cogoni C, Kosilo M, Prata D

Psychoneuroendocrinology18 Jun 2025

PMID40578004 (opens in a new tab)DOI10.1016/j.psyneuen.2025.107519 (opens in a new tab)PepBankPUB-40578004
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In heterosexual men playing a Prisoner's Dilemma, oxytocin increased general cooperation probability versus placebo.

    In plain wordsIn heterosexual men playing a cooperation game, oxytocin increased cooperation more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseGeneral cooperation probability
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT pervasively increased general cooperation probability, as well as cooperation probability specifically after reciprocal cooperation.
    1 context sentence
    Summary · context
    In an EEG experiment with the Prisoner's Dilemma, using a between-subject double-blind placebo-controlled design, we investigated if the sexualization of women could influence cooperative behaviors from heterosexual men (n = 50) and if oxytocin (OT), thought to have a key role in social cognition, m…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In heterosexual men playing a Prisoner's Dilemma, oxytocin increased cooperation probability after reciprocal cooperation versus placebo.

    In plain wordsIn heterosexual men playing a cooperation game, oxytocin increased cooperation after the partner had cooperated, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCooperation probability after reciprocal cooperation
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    as well as cooperation probability specifically after reciprocal cooperation.
    1 context sentence
    Summary · context
    In an EEG experiment with the Prisoner's Dilemma, using a between-subject double-blind placebo-controlled design, we investigated if the sexualization of women could influence cooperative behaviors from heterosexual men (n = 50) and if oxytocin (OT), thought to have a key role in social cognition, m…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In heterosexual men, oxytocin increased cooperation probability after betrayal, particularly with non-sexualized women and when they played before the sexualized women.

    In plain wordsIn heterosexual men, oxytocin increased cooperation after being betrayed, mostly with non-sexualized partners, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCooperation probability after betrayal
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, OT increased cooperation probability after betrayal, particularly for non-sexualized and when they played before the sexualized women.
    1 context sentence
    Summary · context
    In an EEG experiment with the Prisoner's Dilemma, using a between-subject double-blind placebo-controlled design, we investigated if the sexualization of women could influence cooperative behaviors from heterosexual men (n = 50) and if oxytocin (OT), thought to have a key role in social cognition, m…
  4. 04HumanRandomized controlled trialMechanism

    In heterosexual men, oxytocin increased P300 latency when they played with non-sexualized women before the sexualized women.

    In plain wordsIn heterosexual men, oxytocin slowed a brain-wave response to game outcomes in one playing order, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseP300 latency
    Study

    n = 50

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the former's latency was also increased by OT when men played with non-sexualized before the sexualized women
    1 context sentence
    Summary · context
    In an EEG experiment with the Prisoner's Dilemma, using a between-subject double-blind placebo-controlled design, we investigated if the sexualization of women could influence cooperative behaviors from heterosexual men (n = 50) and if oxytocin (OT), thought to have a key role in social cognition, m…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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