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Study · Randomized controlled trial · n = 95 · 2025

5 results

The synergistic effects of acute stress and exogenous oxytocin on males' decision-making under unfairness.

Wang G, Tang J, Yin Z, Yu S, Lu J, Shi X, Hao X, Li S

Psychoneuroendocrinology13 Jun 2025Cited by 1 (Europe PMC)

PMID40541116 (opens in a new tab)DOI10.1016/j.psyneuen.2025.107522 (opens in a new tab)PepBankPUB-40541116
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy young males, exogenous oxytocin inhibited the hypothalamic-pituitary-adrenal axis stress response.

    In plain wordsIn healthy young men, oxytocin dampened the body's hormonal stress response compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseHPA axis stress response
    Study

    n = 95

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    32 IUAs given in this study (human).

    Source sentences

    Summary
    OXT inhibited the hypothalamic-pituitary-adrenal (HPA) axis stress response
    1 context sentence
    Summary · context
    In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young males, exogenous oxytocin enhanced sympathetic nervous system activity.

    In plain wordsIn healthy young men, oxytocin raised activity of the body's fight-or-flight nervous system compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSympathetic nervous system activity
    Study

    n = 95

    Comparator
    Placebo
    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    32 IUAs given in this study (human).

    Source sentences

    Summary
    enhanced sympathetic nervous system activity
    1 context sentence
    Summary · context
    In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy young males, exogenous oxytocin increased subjectively perceived stress.

    In plain wordsIn healthy young men, oxytocin increased how stressed they felt compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseSubjectively perceived stress
    Study

    n = 95

    Comparator
    Placebo
    Outcome group
    Stress hormones · Mental health and mood
    Studied dose
    32 IUAs given in this study (human).

    Source sentences

    Summary
    increased subjectively perceived stress.
    1 context sentence
    Summary · context
    In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy young males, oxytocin and acute stress acted synergistically to reduce acceptance of extremely unfair allocations.

    In plain wordsIn healthy young men, oxytocin plus a stress test made them less willing to accept very unfair offers.

    Peptide
    Oxytocin
    Outcome
    DecreaseAcceptance of extremely unfair allocations in the Ultimatum Game
    Study

    n = 95

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    32 IUAs given in this study (human).

    Source sentences

    Summary
    Stress and OXT acted synergistically, reducing males' acceptance of extremely unfair allocations (¥5)
    1 context sentence
    Summary · context
    In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy young males, oxytocin and acute stress jointly amplified the impact of previous offers on expectations.

    In plain wordsIn healthy young men, oxytocin plus a stress test made earlier offers weigh more on what they expected next.

    Peptide
    Oxytocin
    Outcome
    IncreaseInfluence of previous offers on expectations
    Study

    n = 95

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    32 IUAs given in this study (human).

    Source sentences

    Summary
    amplifying the impact of previous offers on expectations, highlighting the salience of social cues after stress exposure and OXT treatment.
    1 context sentence
    Summary · context
    In this study, 95 healthy young males were randomly assigned to four groups, receiving either 32 IU of exogenous OXT or a placebo (PBO) before undergoing the Trier Social Stress Test (TSST) or a control procedure, followed by participation in the Ultimatum Game (UG) as responders, allocating ¥50.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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