Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.

Luo Z, Ji R, Ye R, Shi Y, Pang Q, Yin M

Sleep and biological rhythms25 Feb 2025Cited by 1 (Europe PMC)

PMID40538389PMCIDPMC12174021DOI10.1007/s41105-025-00578-9PepBankPUB-40538389

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults, serum MOTS‑c levels were reduced in patients with obstructive sleep apnea compared with controls.
In plain wordsIn adults, the body's own MOTS‑c levels were lower in people with sleep apnea than in controls.
Peptide
MOTS-c
Outcome
DecreaseSerum MOTS-c in OSA versus controls
Study
n = 77
Comparator
Controls
Outcome group
Mitochondrial function · Sleep
Source sentences
Title
Reduced serum levels of mitochondria-derived peptide MOTS-c in patients with obstructive sleep apnea.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-seven participants were enrolled in this study, including 53 patients with OSA and 24 controls.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4053838901
02HumanEndogenous levelObservational studyOther
In adults with and without obstructive sleep apnea, serum MOTS‑c levels correlated significantly with BMI, apnea-hypopnea index and oxygen desaturation index, independent of age.
In plain wordsIn adults, the body's own MOTS‑c levels were linked to body mass, apnea severity and oxygen drops during sleep.
Peptide
MOTS-c
Outcome
Direction not reportedCorrelation of serum MOTS-c with BMI, AHI and ODI
Study
n = 77
Outcome group
Mitochondrial function · Sleep
Source sentences
Summary
Analysis revealed that serum MOTS-c levels were significantly correlated with BMI, AHI (Apnea-Hypopnea Index), and ODI (Oxygen Desaturation Index), independent of age.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-seven participants were enrolled in this study, including 53 patients with OSA and 24 controls.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4053838902
03HumanEndogenous levelObservational studyOther
In adults with obstructive sleep apnea, serum MOTS‑c levels were lower in patients with more severe disease.
In plain wordsIn adults with sleep apnea, the body's own MOTS‑c levels were lower when the apnea was more severe.
Peptide
MOTS-c
Outcome
DecreaseSerum MOTS-c by OSA severity
Study
n = 77
Outcome group
Mitochondrial function · Sleep
Source sentences
Summary
Additionally, the severity of OSA was inversely related to serum MOTS-c levels, with lower levels observed in patients with more severe OSA.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-seven participants were enrolled in this study, including 53 patients with OSA and 24 controls.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4053838903
04HumanEndogenous levelObservational studyOther
In adults, serum MOTS‑c levels varied across BMI classifications.
In plain wordsIn adults, the body's own MOTS‑c levels differed between body mass index groups.
Peptide
MOTS-c
Outcome
MixedSerum MOTS-c across BMI classes
Study
n = 77
Outcome group
Mitochondrial function · Sleep
Source sentences
Summary
Variations in serum MOTS-c levels were also noted across different BMI classifications.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-seven participants were enrolled in this study, including 53 patients with OSA and 24 controls.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4053838904
05HumanEndogenous levelObservational studyOther
In adults, OSA severity was an independent factor influencing serum MOTS‑c levels after adjusting for BMI.
In plain wordsIn adults, sleep apnea severity was linked to the body's own MOTS‑c levels even after allowing for body mass.
Peptide
MOTS-c
Outcome
Direction not reportedOSA severity as independent factor for serum MOTS-c (ANCOVA)
Study
n = 77
Outcome group
Mitochondrial function · Sleep
Source sentences
Summary
Analysis of covariance (ANCOVA), with BMI as a covariate, demonstrated that the severity of OSA was an independent factor influencing serum MOTS-c levels.
1 context sentence(design, population, supporting numbers)
Summary · context
Seventy-seven participants were enrolled in this study, including 53 patients with OSA and 24 controls.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-4053838905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

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