A Supramolecular System of Bioactive Ionic Liquid, Peony Extract, and Peptide for Enhanced Permeability and Synergistic Skincare Benefits.

Wang M, Liu T, Wang H, Wang Z, Zhang J

Chemistry (Weinheim an der Bergstrasse, Germany)7 Jul 2025

PMID40522284DOI10.1002/chem.202501323PepBankPUB-40522284

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Argireline (acetyl hexapeptide-8).

01LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In cellular assays, bioactive [Bet][MA] increased AHP8 uptake.
In plain wordsIn cells, the bioactive ionic liquid increased AHP8 uptake.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseCellular uptake
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
While being biosafe, [Bet][MA] significantly increased the transdermal permeation, skin retention, and cellular uptake of AHP8.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4052228403
02LabNot a test of Argireline (acetyl hexapeptide-8) aloneOther designActivity measurement
In laboratory studies, bioactive [Bet][MA] increased AHP8 transdermal permeation.
In plain wordsIn lab tests, the bioactive ionic liquid increased AHP8 passage through skin.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseTransdermal permeation
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
While being biosafe, [Bet][MA] significantly increased the transdermal permeation, skin retention, and cellular uptake of AHP8.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4052228401
03LabNot a test of Argireline (acetyl hexapeptide-8) aloneOther designActivity measurement
In laboratory studies, bioactive [Bet][MA] increased AHP8 skin retention.
In plain wordsIn lab tests, the bioactive ionic liquid increased AHP8 retention in skin.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSkin retention
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
While being biosafe, [Bet][MA] significantly increased the transdermal permeation, skin retention, and cellular uptake of AHP8.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4052228402
04LabNot a test of Argireline (acetyl hexapeptide-8) aloneOther designActivity measurement
In experimental assays, PE/AHP8/[Bet][MA] showed radical and ROS scavenging, collagen production, tissue repair, and inhibition of tyrosinase, motion signaling, and inflammation.
In plain wordsIn experimental tests, the mixture showed antioxidant, collagen-producing, tissue-repair, tyrosinase-inhibiting, motion-signaling-inhibiting, and anti-inflammatory activities.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
Not applicableCombined skincare activity
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The supramolecular PE/AHP8/[Bet][MA] system demonstrated excellent radical- and reactive oxygen species-scavenging capability, collagen production, and tissue repair capability while concurrently inhibiting tyrosinase activity, motion signaling, and inflammation.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4052228405
05Computer modelNot a test of Argireline (acetyl hexapeptide-8) aloneIn silicoMechanism
In calculations, [Bet][MA] intensified AHP8 and PE affinity for target proteins through supramolecular interactions.
In plain wordsComputer calculations indicated that the ionic liquid increased AHP8 and peony extract affinity for target proteins.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseTarget protein affinity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Theoretical calculations revealed that [Bet][MA] improved the anti-wrinkle and whitening efficacies of AHP8 and PE through supramolecular interactions; it modulated their electron cloud distribution and molecular polarity and thus intensified their affinity to target proteins.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4052228404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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