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Study · Animal study (in vivo) · mouse · 2025

10 results

MOTS-c attenuates airway barrier dysfunction in allergic asthma by inhibiting epithelial apoptosis via Nrf2 pathway.

Zhang W, Li S, Zhang Y, Wu Y, Chen D, Pang Q, Han S

International immunopharmacology4 Jun 2025Cited by 6 (Europe PMC)

PMID40472776 (opens in a new tab)DOI10.1016/j.intimp.2025.115014 (opens in a new tab)PepBankPUB-40472776
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study10

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with house dust mite-induced asthma, exogenous MOTS‑c ameliorated lung tissue damage.

    In plain wordsIn mice with asthma, MOTS‑c reduced lung tissue damage.

    Peptide
    MOTS-c
    Outcome
    DecreaseLung tissue damage in HDM asthma mice
    Study

    mousen: not reported in source

    house dust mite asthma model
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous supplementation of MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by HDM.
    1 context sentence
    Summary · context
    C57BL/6 and Nrf2-knockout (Nrf2-/-) mice were stimulated with house dust mites (HDM) to establish an asthma model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with house dust mite-induced asthma, exogenous MOTS‑c ameliorated inflammation.

    In plain wordsIn mice with asthma, MOTS‑c reduced lung inflammation.

    Peptide
    MOTS-c
    Outcome
    DecreaseLung inflammation in HDM asthma mice
    Study

    mousen: not reported in source

    house dust mite asthma model
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous supplementation of MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by HDM.
    1 context sentence
    Summary · context
    C57BL/6 and Nrf2-knockout (Nrf2-/-) mice were stimulated with house dust mites (HDM) to establish an asthma model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with house dust mite-induced asthma, exogenous MOTS‑c ameliorated oxidative stress.

    In plain wordsIn mice with asthma, MOTS‑c reduced oxidative stress in the lungs.

    Peptide
    MOTS-c
    Outcome
    DecreaseLung oxidative stress in HDM asthma mice
    Study

    mousen: not reported in source

    house dust mite asthma model
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous supplementation of MOTS-c significantly ameliorated lung tissue damage, inflammation, and oxidative stress caused by HDM.
    1 context sentence
    Summary · context
    C57BL/6 and Nrf2-knockout (Nrf2-/-) mice were stimulated with house dust mites (HDM) to establish an asthma model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with allergic asthma, MOTS‑c reversed airway barrier dysfunction.

    In plain wordsIn mice with asthma, MOTS‑c reversed damage to the airway barrier.

    Peptide
    MOTS-c
    Outcome
    IncreaseAirway barrier function in AA mice
    Study

    mousen: not reported in source

    house dust mite asthma model
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, MOTS-c reversed the barrier function and mitochondrial damage in AA mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with allergic asthma, MOTS‑c reversed mitochondrial damage.

    In plain wordsIn mice with asthma, MOTS‑c reversed damage to mitochondria in lung cells.

    Peptide
    MOTS-c
    Outcome
    DecreaseMitochondrial damage in AA mice
    Study

    mousen: not reported in source

    house dust mite asthma model
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, MOTS-c reversed the barrier function and mitochondrial damage in AA mice.
  6. 06LabIn vitro (cells)Efficacy outcome

    In house dust mite-stimulated BEAS-2B cells, MOTS‑c significantly inhibited inflammation.

    In plain wordsIn lab airway cells, MOTS‑c reduced inflammation caused by house dust mite.

    Peptide
    MOTS-c
    Outcome
    DecreaseInflammation in HDM-stimulated BEAS-2B cells
    Study

    n: not reported in source

    BEAS-2B cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Furthermore, MOTS-c significantly inhibited inflammation, oxidative stress, and mitochondrial damage in HDM-stimulated BEAS-2B cells.
    1 context sentence
    Summary · context
    BEAS-2B cells were pretreated using 10 μM MOTS-c for 2 h and then treated with HDM (1 μM) for 24 h.
  7. 07LabIn vitro (cells)Efficacy outcome

    In house dust mite-stimulated BEAS-2B cells, MOTS‑c significantly inhibited oxidative stress.

    In plain wordsIn lab airway cells, MOTS‑c reduced oxidative stress caused by house dust mite.

    Peptide
    MOTS-c
    Outcome
    DecreaseOxidative stress in HDM-stimulated BEAS-2B cells
    Study

    n: not reported in source

    BEAS-2B cells
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Furthermore, MOTS-c significantly inhibited inflammation, oxidative stress, and mitochondrial damage in HDM-stimulated BEAS-2B cells.
    1 context sentence
    Summary · context
    BEAS-2B cells were pretreated using 10 μM MOTS-c for 2 h and then treated with HDM (1 μM) for 24 h.
  8. 08LabIn vitro (cells)Efficacy outcome

    In house dust mite-stimulated BEAS-2B cells, MOTS‑c significantly inhibited mitochondrial damage.

    In plain wordsIn lab airway cells, MOTS‑c reduced mitochondrial damage caused by house dust mite.

    Peptide
    MOTS-c
    Outcome
    DecreaseMitochondrial damage in HDM-stimulated BEAS-2B cells
    Study

    n: not reported in source

    BEAS-2B cells
    Outcome group
    Mitochondrial function · Respiratory
    Studied dose
    10 µM · 2 h pretreatmentAs given in this study.

    Source sentences

    Summary
    Furthermore, MOTS-c significantly inhibited inflammation, oxidative stress, and mitochondrial damage in HDM-stimulated BEAS-2B cells.
    1 context sentence
    Summary · context
    BEAS-2B cells were pretreated using 10 μM MOTS-c for 2 h and then treated with HDM (1 μM) for 24 h.
  9. 09LabIn vitro (cells)Mechanism

    MOTS‑c attenuated airway barrier damage in allergic asthma by inhibiting bronchial epithelial apoptosis via the Nrf2 pathway.

    In plain wordsIn lab and animal tests, MOTS‑c protected the airway barrier by reducing airway cell death through the Nrf2 pathway.

    Peptide
    MOTS-c
    Outcome
    DecreaseBronchial epithelial apoptosis via Nrf2
    Study

    n: not reported in source

    bronchial epithelial cells and Nrf2 knockout mice
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, MOTS-c attenuates airway barrier damage in AA by inhibiting bronchial epithelial apoptosis via the Nrf2 pathway.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 10HumanEndogenous levelObservational studyOther

    Serum MOTS‑c levels were lower in patients with asthma than in healthy volunteers.

    In plain wordsIn people with asthma, the body's own MOTS‑c levels were lower than in healthy volunteers.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum MOTS-c in asthma
    Study

    n: not reported in source

    Comparator
    Healthy volunteers
    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    MOTS-c levels were lower in the serum of patients with asthma than in that of healthy volunteers.
    1 context sentence
    Summary · context
    MOTS-c levels in the serum of patients with asthma and healthy volunteers were measured by ELISA.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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