Cerebrolysin-loaded platelet-rich plasma exosomes: Restoring immune homeostasis via TNF-α/IL-10 modulation and apoptosis targeting for spinal cord injury repair.

Akbari-Gharalari N, Aliyari-Serej Z, Ghahremani-Nasab M, Zangbar HS, Yahyavi Y, Nezhadshahmohammad F, Ebrahimi-Kalan A

The journal of spinal cord medicine5 Jun 2025Cited by 5 (Europe PMC)

PMID40470992PMCIDPMC12931343DOI10.1080/10790268.2025.2503053PepBankPUB-40470992

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

01AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In mice with spinal cord injury, Cerebrolysin-loaded exosomes significantly modulated Bax expression.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosomes changed Bax expression.
Peptide
Cerebrolysin
Outcome
Direction not reportedBax expression
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
CLE treatment significantly modulated Bax and Bcl2 expression, reducing apoptosis and enhancing neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099201
02AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In mice with spinal cord injury, Cerebrolysin-loaded exosomes significantly modulated Bcl2 expression.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosomes changed Bcl2 expression.
Peptide
Cerebrolysin
Outcome
Direction not reportedBcl2 expression
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
CLE treatment significantly modulated Bax and Bcl2 expression, reducing apoptosis and enhancing neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099202
03AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice with spinal cord injury, Cerebrolysin-loaded exosomes reduced apoptosis.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosomes reduced programmed cell death.
Peptide
Cerebrolysin
Outcome
DecreaseApoptosis
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
CLE treatment significantly modulated Bax and Bcl2 expression, reducing apoptosis and enhancing neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099203
04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice with spinal cord injury, Cerebrolysin-loaded exosomes enhanced neuronal survival.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosomes improved nerve cell survival.
Peptide
Cerebrolysin
Outcome
IncreaseNeuronal survival
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
CLE treatment significantly modulated Bax and Bcl2 expression, reducing apoptosis and enhancing neuronal survival.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099204
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In mice with spinal cord injury, Cerebrolysin-loaded exosome treatment decreased TNF-α levels.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosome treatment reduced TNF-α levels.
Peptide
Cerebrolysin
Outcome
DecreaseTNF-α levels
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Inflammation markers · Nervous system and cognition
Source sentences
Summary
TNF-α levels decreased, indicating reduced inflammation, while IL-10 levels increased, showing anti-inflammatory effects.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099205
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In mice with spinal cord injury, Cerebrolysin-loaded exosome treatment increased IL-10 levels.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosome treatment increased IL-10 levels.
Peptide
Cerebrolysin
Outcome
IncreaseIL-10 levels
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Immune response · Nervous system and cognition
Source sentences
Summary
TNF-α levels decreased, indicating reduced inflammation, while IL-10 levels increased, showing anti-inflammatory effects.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099206
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice with spinal cord injury, Cerebrolysin-loaded exosome treatment improved tissue organization.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosome treatment improved tissue organization.
Peptide
Cerebrolysin
Outcome
IncreaseTissue organization
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Histological assessment revealed improved tissue organization, and motor function recovery was significantly enhanced as measured by BBB scores.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099207
08AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In mice with spinal cord injury, Cerebrolysin-loaded exosome treatment significantly enhanced motor recovery measured by BBB scores.
In plain wordsIn mice with spinal cord injury, Cerebrolysin-loaded exosome treatment improved motor recovery scores.
Peptide
Cerebrolysin
Outcome
IncreaseBBB motor function
Study
mousen: not reported in source
compression spinal cord injury
Outcome group
Exercise and physical function · Nervous system and cognition
Source sentences
Summary
Histological assessment revealed improved tissue organization, and motor function recovery was significantly enhanced as measured by BBB scores.
2 context sentences(design, population, supporting numbers)
Summary · context
An experimental study using a mouse model of SCI, investigating the effects of Exo, CBL, and CLE treatments.
Summary · context
Mice with induced SCI were treated with Exo, CBL, or CLE.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-4047099208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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