Circulating mitochondrial biomarkers in acute coronary syndrome.

Iboleon-Jimenez A, Sánchez-Quintero MJ, Carmona-Segovia ADM, Sojo B, Fernández-Ramos AM, García-Rodríguez L, Molina-Ramos AI, García-Pinilla JM, Jimenez-Navarro M, Ortega-Gomez A

Frontiers in medicine15 May 2025Cited by 2 (Europe PMC)

PMID40443515PMCIDPMC12119305DOI10.3389/fmed.2025.1568305PepBankPUB-40443515

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Summary

BackgroundAcute coronary syndrome (ACS) is the leading cause of mortality in developed countries. Mitochondrial dysfunction is a hallmark of various cardiometabolic diseases, including ACS. Emerging evidence suggests that evaluating mitochondrial biomarkers in plasma may offer valuable insights into the pathophysiology and management of these conditions. The present study aims to analyse the effect of ACS, sex and their interaction on plasma levels of mitochondrial markers, such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) and citrate syntetase (CS).MethodsA total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study. Venous blood samples were collected from participants after a 12-h overnight fast. Plasma levels of mitochondrial PGC-1α, MOTS-c and CS were measured.ResultsACS significantly reduced plasma levels of PGC-1α and MOTS-c. Sex did not shown a significant effect on these markers. Additionally, MOTS-c positively correlated with the first troponin and hemoglobin, PGC-1α negatively correlated with glucose and positively with HDL-cholesterol, and CS showed negative correlations with NT-proBNP, C-reactive protein, and hemoglobin.ConclusionMitochondria markers, MOTS-c and PGC-1α, are altered in ACS patients, with no observed sex differences. These findings represent an initial step toward integrating personalized medicine into the clinical management of ACS. Nonetheless, further studies are required to fully elucidate the role of these markers in this pathology.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

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Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults, plasma MOTS‑c levels were significantly lower in patients with acute coronary syndrome than in controls.
In plain wordsIn adults with acute coronary syndrome, the body's own MOTS‑c levels were lower than in controls.
Peptide
MOTS-c
Outcome
DecreasePlasma MOTS-c in ACS versus controls
Study
n = 38
Comparator
Controls
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
ACS significantly reduced plasma levels of PGC-1α and MOTS-c.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4044351501
02HumanEndogenous levelObservational studyOther
In adults with and without acute coronary syndrome, sex had no significant effect on plasma MOTS‑c levels.
In plain wordsIn adults, the body's own MOTS‑c levels did not differ significantly between women and men.
Peptide
MOTS-c
Outcome
No significant changeEffect of sex on plasma MOTS-c
Study
n = 38
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Sex did not shown a significant effect on these markers.
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4044351502
03HumanEndogenous levelObservational studyOther
In adults with and without acute coronary syndrome, plasma MOTS‑c correlated positively with first troponin and hemoglobin.
In plain wordsIn adults, higher body's own MOTS‑c levels were linked to higher first troponin and hemoglobin.
Peptide
MOTS-c
Outcome
IncreaseCorrelation of MOTS-c with first troponin and hemoglobin
Study
n = 38
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Additionally, MOTS-c positively correlated with the first troponin and hemoglobin
1 context sentence(design, population, supporting numbers)
Summary · context
A total of 18 ACS patients (8 women and 10 men) and 20 controls (8 women and 12 men) were included in this study.
This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.
Show in the study text Report a problemFND-4044351503

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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