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Study · Animal study (in vivo) · 2025

3 results

Evaluating the Therapeutic Effects of Oxytocin on Animal Model of Alzheimer's Disease: A Systematic Review.

Shafigh E, Sadeghi G, Jamaat NA, Hassanpour F, Solhirad M, Karimi-Zandi L

Current Alzheimer research1 Jan 2025

PMID40417765 (opens in a new tab)DOI10.2174/0115672050386593250521064527 (opens in a new tab)PepBankPUB-40417765
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animal models of Alzheimer's disease, oxytocin administration mitigated memory deficits across the reviewed studies.

    In plain wordsIn animal models of Alzheimer's disease, giving oxytocin reduced memory problems in the reviewed studies.

    Peptide
    Oxytocin
    Outcome
    DecreaseMemory deficits in animal models of Alzheimer's disease
    Study

    n: not reported in source

    Animal models of Alzheimer's disease
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These studies consistently demonstrate that, OXT administration mitigates various memory deficits in animal models of AD.
    1 context sentence
    Summary · context
    Our screening revealed that studies investigating OXT therapy primarily involve animal models.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In animal models of Alzheimer's disease, oxytocin improvements were linked to reduced microglial-driven inflammation.

    In plain wordsIn animal models of Alzheimer's disease, oxytocin's benefits were linked to less inflammation driven by brain immune cells.

    Peptide
    Oxytocin
    Outcome
    DecreaseMicroglial-driven inflammation
    Study

    n: not reported in source

    Animal models of Alzheimer's disease
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced microglial-driven inflammation
    1 context sentence
    Summary · context
    Our screening revealed that studies investigating OXT therapy primarily involve animal models.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In animal models of Alzheimer's disease, oxytocin improvements were linked to decreased amyloid-beta deposition, although plaque load changes did not always match cognitive improvement.

    In plain wordsIn animal models of Alzheimer's disease, oxytocin was linked to less amyloid-beta build-up, but plaque changes did not always match memory gains.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmyloid-beta deposition
    Study

    n: not reported in source

    Animal models of Alzheimer's disease
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These improvements are linked to mechanisms such as reduced microglial-driven inflammation and decreased amyloid-beta (Aβ) deposition, but changes in plaque load do not always correspond directly to cognitive improvement.
    1 context sentence
    Summary · context
    Our screening revealed that studies investigating OXT therapy primarily involve animal models.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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