In mice, dulaglutide showed glucose-lowering efficacy similar to GLP-1-Fc mRNA, which provided prolonged glucose reduction.
In plain wordsIn mice, dulaglutide lowered glucose with similar efficacy to GLP-1-Fc mRNA.
- Peptide
- Dulaglutide (Trulicity)
- Outcome
- Direction not reportedGlucose reduction
- Study
mousen: not reported in source
db/db mice- Comparator
- GLP-1-Fc mRNA
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- Dose not stated
Source sentences
Moreover, the GLP-1-Fc mRNA provided prolonged glucose reduction with similar efficacy to GLP-1 protein drug, dulaglutide.
2 context sentences(design, population, supporting numbers)
The GLP-1-Fc mRNA effectively reduced blood glucose levels and increased GLP-1 receptor expression in db/db mice after both single and repeated administrations.
GLP-1-Fc mRNA and GLP-1-Fc protein (dulaglutide) were administered to C57BL/6J and db/db mice to evaluate protein levels, GLP-1 receptor activity, hypoglycemic effects, and safety using ELISA, lance ultra cAMP assay, blood glucose levels detection, immunofluorescence, and hematoxylin and eosin staining.