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Study · Non-randomized trial · n = 55 · 2025

3 results

Effect of Cerebrolysin on Cognitive Function and Delirium in Coronary Artery Bypass Graft Patients.

Stadnik A, Jezierska M, Płotek W, Siwicka D, Mlak R, Dąbrowski W

Medical science monitor : international medical journal of experimental and clinical research12 May 2025

PMID40350671 (opens in a new tab)PMCIDPMC12083191 (opens in a new tab)DOI10.12659/msm.947864 (opens in a new tab)PepBankPUB-40350671
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In CABG patients, MoCA values at the second assessment were significantly lower in the Cerebrolysin group than in the control group.

    In plain wordsIn CABG patients, cognitive scores at the second assessment were lower with Cerebrolysin than in the control group.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMoCA at second assessment
    Study

    n = 55

    Comparator
    Control group without Cerebrolysin
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    50 ml · Preoperatively and on 4 subsequent consecutive daysAs given in this study (human).

    Measurements

    MoCA median, first reported value
    27
    Second assessment; first value in source pair 27 vs 24; arm mapping unclear
    MoCA median, second reported value
    24
    Second assessment; second value in source pair 27 vs 24; arm mapping unclear
    P value for MoCA at second assessment
    0.0083
    Study group comparison at second assessment; source arm mapping for medians unclear

    Source sentences

    Summary
    Although significantly lower values of the MoCA (medians: 27 vs 24, respectively; P=0.0083) were detected in the study group in the second assessment, the pre- and postoperative MoCA values did not differ between the analyzed groups.
    2 context sentences
    Summary · context
    MATERIAL AND METHODS Adult patients undergoing elective CABG surgery under propofol-based anesthesia were divided into 2 groups: the study group received 50 ml of CER preoperatively and on the 4 subsequent consecutive days, and the control group did not receive CER.
    Summary · context
    Both tests were performed preoperatively, as well as on the 2nd and 5th postoperative days.
  2. 02HumanNon-randomized trialEfficacy outcome

    In CABG patients, preoperative and postoperative MoCA values did not differ between Cerebrolysin and control groups.

    In plain wordsIn CABG patients, cognitive scores before and after surgery did not differ between Cerebrolysin and control groups.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeBetween-group MoCA values
    Study

    n = 55

    Comparator
    CABG patients without Cerebrolysin
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    50 ml · Preoperatively and on 4 subsequent consecutive daysAs given in this study (human).

    Source sentences

    Summary
    Although significantly lower values of the MoCA (medians: 27 vs 24, respectively; P=0.0083) were detected in the study group in the second assessment, the pre- and postoperative MoCA values did not differ between the analyzed groups.
    2 context sentences
    Summary · context
    MATERIAL AND METHODS Adult patients undergoing elective CABG surgery under propofol-based anesthesia were divided into 2 groups: the study group received 50 ml of CER preoperatively and on the 4 subsequent consecutive days, and the control group did not receive CER.
    Summary · context
    Both tests were performed preoperatively, as well as on the 2nd and 5th postoperative days.
  3. 03HumanNon-randomized trialSafety outcome

    In CABG patients, delirium occurred in 3 control patients and none in the Cerebrolysin group, and the difference was not statistically significant.

    In plain wordsIn CABG patients, delirium occurred in 3 controls and none given Cerebrolysin. The difference was not statistically significant.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeDelirium
    Study

    n = 55

    Comparator
    CABG patients without Cerebrolysin
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    50 ml · Preoperatively and on 4 subsequent consecutive daysAs given in this study (human).

    Measurements

    Delirium cases
    3 cases
    Control group

    Source sentences

    Summary
    Delirium occurred in 3 cases, and only in the control group, and the difference was not statistically significant.
    2 context sentences
    Summary · context
    MATERIAL AND METHODS Adult patients undergoing elective CABG surgery under propofol-based anesthesia were divided into 2 groups: the study group received 50 ml of CER preoperatively and on the 4 subsequent consecutive days, and the control group did not receive CER.
    Summary · context
    Both tests were performed preoperatively, as well as on the 2nd and 5th postoperative days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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