Benchmark for Setting ACTH Cell Dosage in Clinical Regenerative Medicine for Post-Operative Hypopituitarism.

Kondo T, Suga H, Takeuchi K, Fuse Y, Sato Y, Hirose T, Hideyuki H, Nagata Y, Saito R

Diseases (Basel, Switzerland)10 Apr 2025

PMID40277822PMCIDPMC12025586DOI10.3390/diseases13040112PepBankPUB-40277822

Summary

Background/objectivesOur objective is to develop hormone-producing pituitary cells that can function in the same manner as the human body and provide more effective treatments than current hormone replacement therapy. We have already established a technique for generating hypothalamic-pituitary organoids using feeder-free human pluripotent stem cells (hPSCs) and demonstrated their effectiveness in vivo through transplantation into hypopituitary mouse models. To prospectively determine the upper limit of transplanting adenohypophyseal cells into humans, we investigated the human maximum secretion capacity of adrenocorticotropic hormone (ACTH) and growth hormone (GH).MethodsWe analyzed data from 28 patients with pituitary adenomas, among whom 16 evinced no abnormality of ACTH secretion and 12 showed no GH secretion on corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone-2 (GHRP-2) stimulation testing.ResultsThe average ACTH peak value after CRH stimulation tests was 97.2 pg/mL, and the average GH peak value after GHRP-2 stimulation tests was 25.1 ng/mL.ConclusionsThese data will likely serve as benchmarks of ACTH and GH secretion when transplanting cultured cells into humans.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

01HumanObservational studyOther
In patients with pituitary adenomas, the average peak growth hormone value after GHRP‑2 stimulation testing was 25.1 ng/mL.
In plain wordsIn people with pituitary adenomas, growth hormone peaked at an average of 25.1 ng/mL after a GHRP‑2 test.
Peptide
GHRP-2
Outcome
Not applicableAverage peak GH value after GHRP-2 stimulation
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Average peak GH
25.1 ng/mL
after GHRP-2 stimulation
Source sentences
Summary
the average GH peak value after GHRP-2 stimulation tests was 25.1 ng/mL.
1 context sentence(design, population, supporting numbers)
Summary · context
We analyzed data from 28 patients with pituitary adenomas, among whom 16 evinced no abnormality of ACTH secretion and 12 showed no GH secretion on corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone-2 (GHRP-2) stimulation testing.
Show in the study text Report a problemFND-4027782201

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.