Unveiling the Therapeutic Potential of Dulaglutide in Mitigating Tacrolimus-Induced Nephrotoxicity Through Targeting the miR-22/HMGB-1/TLR4/MyD88/NF-κB Trajectory.

Abdelhady R, Arab HH, Fakhr Eldeen RR, Shalaby HN, Nawwar DA, Elhemely MA, Sayed RH

Archiv der Pharmazie1 Apr 2025Cited by 2 (Europe PMC)

PMID40205909PMCIDPMC11983086DOI10.1002/ardp.202500023PepBankPUB-40205909

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with tacrolimus nephrotoxicity, dulaglutide reduced serum creatinine versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced blood creatinine versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseSerum creatinine
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Treatment with Dula reduced serum creatinine plus blood urea nitrogen and attenuated Tac-induced renal histopathological changes.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with tacrolimus nephrotoxicity, dulaglutide reduced blood urea nitrogen versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced blood urea nitrogen versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseBlood urea nitrogen
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Treatment with Dula reduced serum creatinine plus blood urea nitrogen and attenuated Tac-induced renal histopathological changes.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, dulaglutide attenuated tacrolimus-induced renal histopathological changes versus vehicle.
In plain wordsIn rats, dulaglutide reduced kidney tissue damage from tacrolimus versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal histopathology
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Kidney function · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Treatment with Dula reduced serum creatinine plus blood urea nitrogen and attenuated Tac-induced renal histopathological changes.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590903
04AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide reduced renal TNF-alpha versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced kidney TNF-alpha versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal TNF-alpha
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Dula treatment also hampered renal inflammation and restored redox homeostasis, as indicated by remarkably reduced tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), and NADPH oxidase 1 levels alongside marked replenishment in reduced glutathione (GSH) content.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590904
05AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide reduced renal interleukin-1 beta versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced kidney interleukin-1 beta versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal interleukin-1 beta
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Inflammation markers · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Dula treatment also hampered renal inflammation and restored redox homeostasis, as indicated by remarkably reduced tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), and NADPH oxidase 1 levels alongside marked replenishment in reduced glutathione (GSH) content.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590905
06AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide reduced renal malondialdehyde versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced kidney malondialdehyde versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal malondialdehyde
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Dula treatment also hampered renal inflammation and restored redox homeostasis, as indicated by remarkably reduced tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), and NADPH oxidase 1 levels alongside marked replenishment in reduced glutathione (GSH) content.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590906
07AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide reduced renal NADPH oxidase 1 versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide reduced kidney NADPH oxidase 1 versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseRenal NADPH oxidase 1
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Dula treatment also hampered renal inflammation and restored redox homeostasis, as indicated by remarkably reduced tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), and NADPH oxidase 1 levels alongside marked replenishment in reduced glutathione (GSH) content.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590907
08AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide replenished renal reduced glutathione versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide increased kidney reduced glutathione versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
IncreaseRenal reduced glutathione
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Oxidative stress · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
Dula treatment also hampered renal inflammation and restored redox homeostasis, as indicated by remarkably reduced tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), malondialdehyde (MDA), and NADPH oxidase 1 levels alongside marked replenishment in reduced glutathione (GSH) content.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590908
09AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide upregulated miR-22 expression versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide increased miR-22 expression versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
IncreasemiR-22 expression
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
These effects were mediated through the upregulation of miR-22 expression and the consequent inhibition of the HMGB-1/TLR4/MyD88/NF-κB trajectory.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590909
10AnimalAnimal study (in vivo)Mechanism
In rats with tacrolimus nephrotoxicity, dulaglutide inhibited the HMGB-1/TLR4/MyD88/NF-kappa B pathway versus vehicle.
In plain wordsIn rats with tacrolimus kidney injury, dulaglutide inhibited the reported inflammatory pathway versus vehicle.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseHMGB-1/TLR4/MyD88/NF-kappa B pathway
Study
ratn: not reported in source
Tacrolimus-induced nephrotoxicity
Comparator
Tacrolimus plus vehicle
Outcome group
Receptor activity and mechanism · Kidney and urinary
Studied dose
0.2 mg/kg once a week · 14 daysAs given in this study (rat).
Source sentences
Summary
These effects were mediated through the upregulation of miR-22 expression and the consequent inhibition of the HMGB-1/TLR4/MyD88/NF-κB trajectory.
2 context sentences(design, population, supporting numbers)
Summary · context
The present study aimed to investigate the potential protective role of the GLP-1 agonist, dulaglutide (Dula), against Tac-induced nephrotoxicity in rats.
Summary · context
Rats were administered Tac (5 mg/kg/day) and vehicle or Dula (0.2 mg/kg once a week) for 14 days.
Report a problemFND-4020590910

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Unveiling the Therapeutic Potential of Dulaglutide in Mitigating Tacrolimus-Induced Nephrotoxicity Through Targeting the miR-22/HMGB-1/TLR4/MyD88/NF-κB Trajectory.

Summary

Results from this study10

Version history

Subjects

Publication types

MeSH terms

Keywords