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Study · Animal study (in vivo) · rat · 2025

4 results

Cerebrolysin Induces Dendritic Tree Plastic Changes and BDNF Increase in the Amygdala of Male Rats with Maternal Deprivation.

Cárdenas-Bedoya J, Torres-Mendoza BM, Martínez-Torres NI

Neurochemical research24 Mar 2025Cited by 2 (Europe PMC)

PMID40123021 (opens in a new tab)DOI10.1007/s11064-025-04376-0 (opens in a new tab)PepBankPUB-40123021
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In intact male rats, Cerebrolysin increased social behavior and incidences.

    In plain wordsIn intact male rats, Cerebrolysin increased social behavior and incidences compared with intact rats without Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSocial behavior in intact rats
    Study

    ratn = 14

    male Sprague-Dawley rats
    Comparator
    Intact rats without Cerebrolysin
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · 10 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    CBL treatment had an augmentative effect on intact animals in terms of social behavior and incidences, but no differences between MD and CBL-treated animals.
    2 context sentences
    Summary · context
    In this study, maternal deprivation (MD) was conducted on 9-day-old male Sprague-Dawley rats (n = 28; 7 rats per group: Intact, Intact + CBL, MD, and MD + CBL).
    Summary · context
    At 25 postnatal days (PND), CBL treatment was administered for 10 consecutive days, and social behavior was evaluated in a three-chamber social test at 35 PND.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats with maternal deprivation, social behavior did not differ with Cerebrolysin treatment.

    In plain wordsIn male rats with maternal deprivation, social behavior did not differ between Cerebrolysin and no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeSocial behavior after maternal deprivation
    Study

    ratn = 14

    male Sprague-Dawley rats
    Comparator
    Maternal deprivation without Cerebrolysin
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · 10 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    CBL treatment had an augmentative effect on intact animals in terms of social behavior and incidences, but no differences between MD and CBL-treated animals.
    2 context sentences
    Summary · context
    In this study, maternal deprivation (MD) was conducted on 9-day-old male Sprague-Dawley rats (n = 28; 7 rats per group: Intact, Intact + CBL, MD, and MD + CBL).
    Summary · context
    At 25 postnatal days (PND), CBL treatment was administered for 10 consecutive days, and social behavior was evaluated in a three-chamber social test at 35 PND.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats with maternal deprivation, Cerebrolysin increased amygdala dendritic intersections.

    In plain wordsIn male rats with maternal deprivation, Cerebrolysin increased amygdala dendritic intersections compared with no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAmygdala dendritic intersections
    Study

    ratn = 14

    male Sprague-Dawley rats
    Comparator
    Maternal deprivation without Cerebrolysin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, dendritic intersections and BDNF decreased after the MD protocol but increased by CBL treatment in MD animals.
    2 context sentences
    Summary · context
    In this study, maternal deprivation (MD) was conducted on 9-day-old male Sprague-Dawley rats (n = 28; 7 rats per group: Intact, Intact + CBL, MD, and MD + CBL).
    Summary · context
    At 25 postnatal days (PND), CBL treatment was administered for 10 consecutive days, and social behavior was evaluated in a three-chamber social test at 35 PND.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats with maternal deprivation, Cerebrolysin increased amygdala BDNF.

    In plain wordsIn male rats with maternal deprivation, Cerebrolysin increased amygdala BDNF compared with no Cerebrolysin.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAmygdala BDNF
    Study

    ratn = 14

    male Sprague-Dawley rats
    Comparator
    Maternal deprivation without Cerebrolysin
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 10 consecutive daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, dendritic intersections and BDNF decreased after the MD protocol but increased by CBL treatment in MD animals.
    2 context sentences
    Summary · context
    In this study, maternal deprivation (MD) was conducted on 9-day-old male Sprague-Dawley rats (n = 28; 7 rats per group: Intact, Intact + CBL, MD, and MD + CBL).
    Summary · context
    At 25 postnatal days (PND), CBL treatment was administered for 10 consecutive days, and social behavior was evaluated in a three-chamber social test at 35 PND.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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