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Study · Measured the body's own peptide · 2025

1 result

Circulating PGC-1α and MOTS-c Peptide as Potential Mitochondrial Biomarkers in Patients Undergoing Aortic Valve Replacement.

Sánchez-Quintero MJ, Iboleón A, Martín Chaves L, Pozo Vilumbrales B, Carmona-Segovia ADM, Martínez López P, Romero-Cuevas M, Rodríguez-Capitán J, Becerra-Muñoz VM, Pavón-Morón FJ, Murri M

Biologics : targets & therapy13 Mar 2025Cited by 4 (Europe PMC)

PMID40104672 (opens in a new tab)PMCIDPMC11914779 (opens in a new tab)DOI10.2147/btt.s504289 (opens in a new tab)PepBankPUB-40104672
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with aortic valve disease scheduled for valve replacement, plasma MOTS‑c was significantly lower than in healthy controls.

    In plain wordsIn patients with aortic valve disease, the body's own MOTS‑c levels were lower than in healthy people.

    Peptide
    MOTS-c
    Outcome
    DecreasePlasma MOTS-c in aortic valve disease
    Study

    n = 39

    Comparator
    Healthy controls
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    We observed significantly reduced levels of both proteins in patients, suggesting that substantial mitochondrial dysfunction occurs in AVD patients, independent of sex or age, but directly related to the disease.
    2 context sentences
    Summary · context
    We recruited 17 patients diagnosed with AVD and scheduled for aortic valve replacement, and 22 healthy controls.
    Summary · context
    Plasma levels of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and mitochondrial open reading frame of the 12S rRNA type-c peptide (MOTS-c) were measured by ELISA.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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