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Study · In vitro (cells) · 2025

10 results

Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway.

Sung J, Ju SY, Park S, Jung WK, Je JY, Lee SJ

Tissue & cell6 Mar 2025Cited by 3 (Europe PMC)

PMID40073467 (opens in a new tab)DOI10.1016/j.tice.2025.102837 (opens in a new tab)PepBankPUB-40073467
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HaCaT keratinocytes exposed to PM10, KPV at 50 μg/mL restored cell viability.

    In plain wordsIn lab tests on skin cells, KPV restored cell survival after fine-dust exposure.

    Peptide
    KPV
    Outcome
    IncreaseCell viability under PM10 exposure
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Comparator
    PM10-exposed cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    50 μg/mLAs given in this study.

    Source sentences

    Summary
    Notably, treatment with 50 μg/mL of KPV restored cell viability and reduced IL-1β secretion disrupted by PM10 exposure.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  2. 02LabIn vitro (cells)Activity measurement

    In HaCaT keratinocytes exposed to PM10, KPV at 50 μg/mL reduced IL-1β secretion.

    In plain wordsIn lab tests on skin cells, KPV lowered release of the inflammatory signal IL-1β after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseIL-1β secretion
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Comparator
    PM10-exposed cells
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    50 μg/mLAs given in this study.

    Source sentences

    Summary
    Notably, treatment with 50 μg/mL of KPV restored cell viability and reduced IL-1β secretion disrupted by PM10 exposure.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  3. 03LabIn vitro (cells)Mechanism

    In HaCaT keratinocytes exposed to PM10, KPV inhibited reactive oxygen species production.

    In plain wordsIn lab tests on skin cells, KPV lowered production of reactive oxygen species after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseReactive oxygen species production
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To counteract PM10-induced cell death, KPV inhibited reactive oxygen species (ROS) production, which is responsible for activating extracellular signal-regulated kinase and p38 mitogen-activated protein kinase.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  4. 04LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV decreased expression of the apoptosis-related protein Bax.

    In plain wordsIn lab tests on skin cells, KPV lowered a cell-death protein after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseBax expression
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, KPV decreased the expression of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and IL-1β through suppression of the redox-sensitive transcription factor nuclear, factor-kappa B in PM10-treated HaCaT cells.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  5. 05LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV decreased expression of the apoptosis-related protein Bcl-2.

    In plain wordsIn lab tests on skin cells, KPV lowered the cell-death regulator Bcl-2 after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseBcl-2 expression
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, KPV decreased the expression of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and IL-1β through suppression of the redox-sensitive transcription factor nuclear, factor-kappa B in PM10-treated HaCaT cells.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  6. 06LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV decreased expression of cleaved caspase-3.

    In plain wordsIn lab tests on skin cells, KPV lowered a cell-death marker after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseCleaved caspase-3 expression
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, KPV decreased the expression of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and IL-1β through suppression of the redox-sensitive transcription factor nuclear, factor-kappa B in PM10-treated HaCaT cells.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  7. 07LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV decreased IL-1β expression through suppression of NF-κB.

    In plain wordsIn lab tests on skin cells, KPV lowered the inflammatory signal IL-1β after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseIL-1β expression
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, KPV decreased the expression of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and IL-1β through suppression of the redox-sensitive transcription factor nuclear, factor-kappa B in PM10-treated HaCaT cells.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  8. 08LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV suppressed the redox-sensitive transcription factor NF-κB.

    In plain wordsIn lab tests on skin cells, KPV dampened the inflammation switch NF-κB after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseNF-κB activity
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, KPV decreased the expression of apoptosis-related proteins (Bax, Bcl-2, and cleaved caspase-3) and IL-1β through suppression of the redox-sensitive transcription factor nuclear, factor-kappa B in PM10-treated HaCaT cells.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  9. 09LabIn vitro (cells)Mechanism

    In PM10-treated HaCaT cells, KPV blocked ROS-mediated caspase-1 activation, reducing IL-1β secretion.

    In plain wordsIn lab tests on skin cells, KPV blocked caspase-1, an inflammation enzyme, after fine-dust exposure.

    Peptide
    KPV
    Outcome
    DecreaseCaspase-1 activation
    Study

    n: not reported in source

    human HaCaT keratinocytes
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Against PM10-induced inflammation, KPV effectively blocked ROS-mediated caspase-1 activation, reducing IL-1β secretion.
    1 context sentence
    Summary · context
    In this study, we investigated the protective effects of Lysine-Proline-Valine (KPV)-an endogenous peptide derived from α-melanocyte-stimulating hormone-against oxidative damage and inflammation induced by fine PM (PM10) in human HaCaT keratinocytes.
  10. 10LabIn vitro (cells)Activity measurement

    In a three-dimensional skin model, KPV attenuated inflammatory cell death induced by PM10.

    In plain wordsIn a lab-grown skin model, KPV reduced inflammatory cell death caused by fine dust.

    Peptide
    KPV
    Outcome
    DecreasePM10-induced inflammatory cell death in 3D skin model
    Study

    n: not reported in source

    3D skin model
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a three-dimensional (3D) skin model, KPV treatment effectively attenuated the inflammatory cell death induced by PM10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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