Skip to content

Study · Ex vivo tissue · 2025

3 results

FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.

Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L

Communications biology24 Feb 2025Cited by 16 (Europe PMC)

PMID39994346 (opens in a new tab)PMCIDPMC11850796 (opens in a new tab)DOI10.1038/s42003-025-07738-0 (opens in a new tab)PepBankPUB-39994346
Read at sourcePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In pro-senescence models of keloid organ cultures and fibroblasts, FOXO4‑DRI promoted apoptosis.

    In plain wordsIn lab tests on keloid tissue cultures and cells, FOXO4‑DRI increased cell death.

    Peptide
    FOXO4-DRI
    Outcome
    IncreaseApoptosis of senescent keloid cells
    Study

    n: not reported in source

    Pro-senescence models of keloid organ cultures and fibroblasts
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion.
  2. 02LabEx vivo tissueMechanism

    In pro-senescence models of keloid organ cultures and fibroblasts, FOXO4‑DRI decreased the proportion of G0/G1 phase cells.

    In plain wordsIn lab tests on keloid tissue cultures and cells, FOXO4‑DRI reduced the number of cells in the resting growth phase.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseG0/G1 phase cells
    Study

    n: not reported in source

    Pro-senescence models of keloid organ cultures and fibroblasts
    Outcome group
    Cell viability and death · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion.
  3. 03LabEx vivo tissueMechanism

    In pro-senescence models of keloid organ cultures and fibroblasts, FOXO4‑DRI was accompanied by nuclear exclusion of p53-pS15.

    In plain wordsIn lab tests on keloid tissue cultures and cells, p53-pS15 left the cell nucleus after FOXO4‑DRI treatment.

    Peptide
    FOXO4-DRI
    Outcome
    DecreaseNuclear p53-pS15
    Study

    n: not reported in source

    Pro-senescence models of keloid organ cultures and fibroblasts
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We further demonstrate that a senolytic FOXO4-D-retro-inverso-isoform peptide (FOXO4-DRI) promotes apoptosis and decreases G0/G1 phase cells in pro-senescence models of keloid organ cultures and fibroblasts, accompanied with p53-pS15 nuclear exclusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.