Skip to content

Study · Not a test of the peptide alone · 2025

8 results

Pioneering ionic liquids in neuro-soothing: Enhanced transdermal delivery of collagen peptides and their synergistic anti-aging functions.

Wang M, Wang Z, Liu T, Zhao Y, Sun X, Lu B, Zhang J, Liu Z, Zhang J

Materials today. Bio27 Jan 2025

PMID39968525 (opens in a new tab)PMCIDPMC11834113 (opens in a new tab)DOI10.1016/j.mtbio.2025.101527 (opens in a new tab)PepBankPUB-39968525
Download PDFPubMedAsk about this study
Jump to 8 results

Summary

Facial wrinkles include static and dynamic lines formed through different mechanisms and require diverse treatment approaches. Peptides perform well in anti-aging and wrinkle removal but exhibit poor transdermal efficiency. In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production. This treatment aims to remove dynamic and static lines simultaneously, and the human endogenous feature of GABA, LA, and hexapeptide-9 guarantees high biosafety of the system. The in-vitro transdermal, cellular, animal, and clinical experiments indicate that GALA is a safe and effective enhancer. GALA enhances the local penetration of hexapeptide-9 by altering the skin barrier structure, resulting in cumulative permeation and subcutaneous retention, respectively, 4.79 and 7.89 folds of that without enhancers after 12 h. GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers. Therefore, the combination of GALA and hexapeptide-9 has excellent potential in anti-wrinkle and antiaging treatments. This work's experimental and theoretical studies will further advance the clinical use of bioactive ionic liquids as transdermal enhancers.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexapeptide-9.

  1. 01AnimalNot a test of Hexapeptide-9 aloneOther designMechanism

    In experimental models, GALA with hexapeptide‑9 activated the PPAR signaling pathway.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 activated the PPAR signaling pathway.

    Peptide
    Hexapeptide-9
    Outcome
    IncreasePPAR signaling pathway activation
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  2. 02AnimalNot a test of Hexapeptide-9 aloneOther designEfficacy outcome

    In experimental models, GALA with hexapeptide‑9 reduced ultraviolet-induced oxidative stress.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 reduced ultraviolet-induced oxidative stress.

    Peptide
    Hexapeptide-9
    Outcome
    DecreaseUltraviolet-induced oxidative stress
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  3. 03AnimalNot a test of Hexapeptide-9 aloneOther designEfficacy outcome

    In experimental models, GALA with hexapeptide‑9 reduced inflammation.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 reduced inflammation.

    Peptide
    Hexapeptide-9
    Outcome
    DecreaseInflammation
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  4. 04AnimalNot a test of Hexapeptide-9 aloneOther designEfficacy outcome

    In experimental models, GALA with hexapeptide‑9 reduced epidermal hyperplasia.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 reduced epidermal hyperplasia.

    Peptide
    Hexapeptide-9
    Outcome
    DecreaseEpidermal hyperplasia
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  5. 05AnimalNot a test of Hexapeptide-9 aloneOther designEfficacy outcome

    In experimental models, GALA with hexapeptide‑9 reduced collagen degradation.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 reduced collagen degradation.

    Peptide
    Hexapeptide-9
    Outcome
    DecreaseCollagen degradation
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  6. 06AnimalNot a test of Hexapeptide-9 aloneOther designEfficacy outcome

    In experimental models, GALA with hexapeptide‑9 reduced elastic fiber degradation.

    In plain wordsIn experimental models, GALA with hexapeptide‑9 reduced elastic fiber degradation.

    Peptide
    Hexapeptide-9
    Outcome
    DecreaseElastic fiber degradation
    Study

    n: not reported in source

    Ultraviolet-induced aging experiments, model not assigned to this result
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA also enables hexapeptide-9 to combat root aging, mainly by activating the PPAR signaling pathway, leading to lower degrees of ultraviolet-induced oxidative stress, inflammation, epidermal hyperplasia, and the degradation of collagen and elastic fibers.
    1 context sentence
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  7. 07LabNot a test of Hexapeptide-9 aloneEx vivo tissueEfficacy outcome

    In lab tests, GALA increased cumulative hexapeptide‑9 permeation to 4.79 folds of that without enhancers after 12 h.

    In plain wordsIn lab tests, GALA increased hexapeptide‑9 permeation to 4.79 folds of that without enhancers after 12 h.

    Peptide
    Hexapeptide-9
    Outcome
    IncreaseCumulative permeation
    Study

    n: not reported in source

    In-vitro transdermal experiments
    Comparator
    Hexapeptide-9 without enhancers
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA enhances the local penetration of hexapeptide-9 by altering the skin barrier structure, resulting in cumulative permeation and subcutaneous retention, respectively, 4.79 and 7.89 folds of that without enhancers after 12 h.
    2 context sentences
    Summary · context
    The in-vitro transdermal, cellular, animal, and clinical experiments indicate that GALA is a safe and effective enhancer.
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

  8. 08LabNot a test of Hexapeptide-9 aloneEx vivo tissueEfficacy outcome

    In lab tests, GALA increased subcutaneous hexapeptide‑9 retention to 7.89 folds of that without enhancers after 12 h.

    In plain wordsIn lab tests, GALA increased hexapeptide‑9 retention to 7.89 folds of that without enhancers after 12 h.

    Peptide
    Hexapeptide-9
    Outcome
    IncreaseSubcutaneous retention
    Study

    n: not reported in source

    In-vitro transdermal experiments
    Comparator
    Hexapeptide-9 without enhancers
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    GALA enhances the local penetration of hexapeptide-9 by altering the skin barrier structure, resulting in cumulative permeation and subcutaneous retention, respectively, 4.79 and 7.89 folds of that without enhancers after 12 h.
    2 context sentences
    Summary · context
    The in-vitro transdermal, cellular, animal, and clinical experiments indicate that GALA is a safe and effective enhancer.
    Summary · context
    In this work, a novel neuro-soothing ionic liquid, GALA, prepared from γ-aminobutyric acid (GABA) and lactic acid (LA), is applied in the transdermal delivery of hexapeptide-9, which promotes collagen production.

    In this study, Hexapeptide-9 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexapeptide-9.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.