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Study · In vitro (cells) · 2025

11 results

Mechanisms of ARA290 in counteracting cadmium-triggered neurotoxicity in PC12 cells.

Motafeghi F, Fakhri B MS, Ghassemi Barghi N

Toxicology research17 Feb 2025Cited by 7 (Europe PMC)

PMID39968520 (opens in a new tab)PMCIDPMC11831023 (opens in a new tab)DOI10.1093/toxres/tfaf023 (opens in a new tab)PepBankPUB-39968520
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to cadmium, ARA290 pretreatment significantly improved cell viability.

    In plain wordsIn cells exposed to cadmium, ARA290 pretreatment kept more cells alive.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseCell viability (MTT assay)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PC12 cells pretreated with ARA290 showed significantly improved cell viability in the MTT assay, indicating reduced cytotoxicity.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  2. 02LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to cadmium, ARA290 decreased DNA damage in the comet assay.

    In plain wordsIn cells exposed to cadmium, ARA290 reduced DNA damage.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseDNA damage (comet assay)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The comet assay revealed decreased DNA damage, suggesting reduced genotoxicity.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  3. 03LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 reduced reactive oxygen species levels.

    In plain wordsIn cells exposed to cadmium, ARA290 lowered harmful reactive oxygen molecules.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseReactive oxygen species
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 also alleviated oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside increased glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activities.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  4. 04LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 reduced malondialdehyde levels.

    In plain wordsIn cells exposed to cadmium, ARA290 lowered a marker of oxidative damage (MDA).

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseMalondialdehyde (MDA)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 also alleviated oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside increased glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activities.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  5. 05LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 increased glutathione.

    In plain wordsIn cells exposed to cadmium, ARA290 raised levels of the antioxidant glutathione.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseGlutathione (GSH)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 also alleviated oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside increased glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activities.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  6. 06LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 increased total antioxidant capacity.

    In plain wordsIn cells exposed to cadmium, ARA290 raised the total antioxidant capacity.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseTotal antioxidant capacity (TAC)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 also alleviated oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside increased glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activities.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  7. 07LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 increased superoxide dismutase activity.

    In plain wordsIn cells exposed to cadmium, ARA290 raised the activity of the antioxidant enzyme SOD.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseSuperoxide dismutase (SOD) activity
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 also alleviated oxidative stress, as evidenced by reduced levels of reactive oxygen species (ROS) and malondialdehyde (MDA), alongside increased glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) activities.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  8. 08LabIn vitro (cells)Efficacy outcome

    In PC12 cells exposed to cadmium, ARA290 significantly reduced TUNEL-positive apoptotic cells.

    In plain wordsIn cells exposed to cadmium, ARA290 reduced the number of dying cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseApoptosis (TUNEL-positive cells)
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A marker of apoptosis, TUNEL-positive cells, was significantly reduced.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  9. 09LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 decreased TNF alpha.

    In plain wordsIn cells exposed to cadmium, ARA290 lowered the inflammatory marker TNF alpha.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTNF alpha level
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, ARA290 decreased inflammatory markers such as TNF alpha, IL1ß and IL 6.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  10. 10LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 decreased IL-1β.

    In plain wordsIn cells exposed to cadmium, ARA290 lowered the inflammatory marker IL-1β.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIL-1β level
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, ARA290 decreased inflammatory markers such as TNF alpha, IL1ß and IL 6.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.
  11. 11LabIn vitro (cells)Mechanism

    In PC12 cells exposed to cadmium, ARA290 decreased IL-6.

    In plain wordsIn cells exposed to cadmium, ARA290 lowered the inflammatory marker IL-6.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIL-6 level
    Study

    n: not reported in source

    PC12 cells exposed to cadmium
    Comparator
    Cadmium without ARA290
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, ARA290 decreased inflammatory markers such as TNF alpha, IL1ß and IL 6.
    1 context sentence
    Summary · context
    This study explored ARA290's neuroprotective effects against cadmium-induced toxicity in PC12 cells, an in vitro model for neuronal health.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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