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Study · Animal study (in vivo) · mouse · 2025

22 results

Reduction in minipubertal gonadotropin levels alters reproductive lifespan and ovarian follicular loss in female mice.

Chester M, Devillers MM, Corre R, Giton F, Souaré F, Petrovic CH, Airaud É, Quintas D, Mhaouty-Kodja S, Naulé L, Guigon CJ

Human reproduction (Oxford, England)1 Apr 2025Cited by 6 (Europe PMC)

PMID39948193 (opens in a new tab)PMCIDPMC11965786 (opens in a new tab)DOI10.1093/humrep/deaf019 (opens in a new tab)PepBankPUB-39948193
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study22

22 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, minipubertal ganirelix did not affect puberty initiation, estrous cyclicity or early reproductive fertility versus controls.

    In plain wordsIn mice, ganirelix did not change puberty onset, reproductive cycles or early fertility compared with controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeEarly puberty, estrous cyclicity and fertility
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Our results show that the treatment had no impact on the initiation of puberty, estrous cyclicity, or fertility at the beginning of reproductive life.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, 33% of ganirelix-treated females remained fertile at 11 months versus 6% of controls (P = 0.0471).

    In plain wordsIn mice, more ganirelix-treated females remained fertile at 11 months than controls.

    Peptide
    Ganirelix
    Outcome
    IncreaseFertility at 11 months
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, it increased reproductive lifespan, as shown by the higher percentage of antagonist-treated females than CTRs still fertile at 11 months of age (33% versus 6%; P = 0.0471).
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix did not significantly change hypothalamic kisspeptin neuron numbers versus controls at 4 or 11 months.

    In plain wordsIn mice, ganirelix did not change kisspeptin neuron numbers compared with controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeKisspeptin neuron number
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    There were no significant differences in the number of kisspeptin and GnRH neurons, nor in the density of kisspeptin- and GnRH-immunoreactive neurons in the hypothalamic areas involved in reproduction between the two groups of mice studied at either 4 or 11 months.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix did not significantly change hypothalamic GnRH neuron numbers versus controls at 4 or 11 months.

    In plain wordsIn mice, ganirelix did not change GnRH neuron numbers compared with controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeGnRH neuron number
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    There were no significant differences in the number of kisspeptin and GnRH neurons, nor in the density of kisspeptin- and GnRH-immunoreactive neurons in the hypothalamic areas involved in reproduction between the two groups of mice studied at either 4 or 11 months.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix did not significantly change kisspeptin-immunoreactive neuron density versus controls at 4 or 11 months.

    In plain wordsIn mice, ganirelix did not change kisspeptin neuron density compared with controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeKisspeptin-immunoreactive neuron density
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    There were no significant differences in the number of kisspeptin and GnRH neurons, nor in the density of kisspeptin- and GnRH-immunoreactive neurons in the hypothalamic areas involved in reproduction between the two groups of mice studied at either 4 or 11 months.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix did not significantly change GnRH-immunoreactive neuron density versus controls at 4 or 11 months.

    In plain wordsIn mice, ganirelix did not change GnRH neuron density compared with controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeGnRH-immunoreactive neuron density
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    There were no significant differences in the number of kisspeptin and GnRH neurons, nor in the density of kisspeptin- and GnRH-immunoreactive neurons in the hypothalamic areas involved in reproduction between the two groups of mice studied at either 4 or 11 months.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, basal FSH after ganirelix was comparable to controls at 4 and 11 months.

    In plain wordsIn mice, FSH after ganirelix was similar to controls.

    Peptide
    Ganirelix
    Outcome
    Direction not reportedBasal FSH
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, basal levels of FSH were comparable between the two groups at 4 and 11 months, but not those of LH at 11 months which were much lower in females treated with antagonist than in their age-matched CTRs (237 ± 59.6 pg/ml in antagonist-treated females versus 1027 ± 226.3 pg/ml in CTRs, P = 0.0069).
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice at 11 months, basal LH was 237 ± 59.6 pg/ml after ganirelix versus 1027 ± 226.3 pg/ml in controls (P = 0.0069).

    In plain wordsIn mice at 11 months, ganirelix lowered LH compared with age-matched controls.

    Peptide
    Ganirelix
    Outcome
    DecreaseBasal LH at 11 months versus age-matched controls
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    In addition, basal levels of FSH were comparable between the two groups at 4 and 11 months, but not those of LH at 11 months which were much lower in females treated with antagonist than in their age-matched CTRs (237 ± 59.6 pg/ml in antagonist-treated females versus 1027 ± 226.3 pg/ml in CTRs, P = 0.0069).
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice at 11 months, LH after ganirelix was comparable to young mice, including 4-month-old controls at 294 ± 71.75 pg/ml (P > 0.05).

    In plain wordsIn mice at 11 months, LH after ganirelix was similar to young mice.

    Peptide
    Ganirelix
    Outcome
    No significant changeBasal LH versus young mice
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Young mice, including 4-month-old controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Importantly, at this age, antagonist-treated mice had basal LH levels comparable to young mice (e.g. in 4-month-old CTRs: 294 ± 71.75 pg/ml, P > 0.05).
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix-treated females had fewer primordial follicles than controls.

    In plain wordsIn mice, ganirelix-treated females had fewer primordial follicles than controls.

    Peptide
    Ganirelix
    Outcome
    DecreasePrimordial follicles
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Despite their prolonged reproductive lifespan and delayed neuroendocrine aging, antagonist-treated mice exhibited earlier depletion of their follicles, as shown by lower numbers of primordial, primary, and preantral follicles associated with lower circulating AMH levels and relative intra-ovarian ab…
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix-treated females had fewer primary follicles than controls.

    In plain wordsIn mice, ganirelix-treated females had fewer primary follicles than controls.

    Peptide
    Ganirelix
    Outcome
    DecreasePrimary follicles
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Despite their prolonged reproductive lifespan and delayed neuroendocrine aging, antagonist-treated mice exhibited earlier depletion of their follicles, as shown by lower numbers of primordial, primary, and preantral follicles associated with lower circulating AMH levels and relative intra-ovarian ab…
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix-treated females had fewer preantral follicles than controls.

    In plain wordsIn mice, ganirelix-treated females had fewer preantral follicles than controls.

    Peptide
    Ganirelix
    Outcome
    DecreasePreantral follicles
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Despite their prolonged reproductive lifespan and delayed neuroendocrine aging, antagonist-treated mice exhibited earlier depletion of their follicles, as shown by lower numbers of primordial, primary, and preantral follicles associated with lower circulating AMH levels and relative intra-ovarian ab…
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix-treated females had lower circulating AMH than controls.

    In plain wordsIn mice, ganirelix-treated females had lower AMH than controls.

    Peptide
    Ganirelix
    Outcome
    DecreaseCirculating AMH
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Despite their prolonged reproductive lifespan and delayed neuroendocrine aging, antagonist-treated mice exhibited earlier depletion of their follicles, as shown by lower numbers of primordial, primary, and preantral follicles associated with lower circulating AMH levels and relative intra-ovarian ab…
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ganirelix-treated females had lower intra-ovarian Amh transcript abundance than controls.

    In plain wordsIn mice, ganirelix-treated females had fewer ovarian Amh transcripts than controls.

    Peptide
    Ganirelix
    Outcome
    DecreaseIntra-ovarian Amh transcripts
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    Despite their prolonged reproductive lifespan and delayed neuroendocrine aging, antagonist-treated mice exhibited earlier depletion of their follicles, as shown by lower numbers of primordial, primary, and preantral follicles associated with lower circulating AMH levels and relative intra-ovarian ab…
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In mice, antral follicle numbers after ganirelix remained similar to controls.

    In plain wordsIn mice, antral follicle numbers after ganirelix were similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeAntral follicles
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In mice, corpora lutea numbers after ganirelix remained similar to controls.

    In plain wordsIn mice, corpora lutea numbers after ganirelix were similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeCorpora lutea
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intra-ovarian Cyp19a1 transcript abundance after ganirelix remained similar to controls.

    In plain wordsIn mice, ovarian Cyp19a1 transcripts after ganirelix were similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeCyp19a1 transcripts
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  18. 18AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intra-ovarian Inhba transcript abundance after ganirelix remained similar to controls.

    In plain wordsIn mice, ovarian Inhba transcripts after ganirelix were similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeInhba transcripts
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  19. 19AnimalAnimal study (in vivo)Efficacy outcome

    In mice, intra-ovarian Inhbb transcript abundance after ganirelix remained similar to controls.

    In plain wordsIn mice, ovarian Inhbb transcripts after ganirelix were similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeInhbb transcripts
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  20. 20AnimalAnimal study (in vivo)Efficacy outcome

    In mice, circulating progesterone after ganirelix remained similar to controls.

    In plain wordsIn mice, progesterone after ganirelix was similar to controls.

    Peptide
    Ganirelix
    Outcome
    No significant changeCirculating progesterone
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    However, they exhibited comparable completion of folliculogenesis, as suggested by the numbers of antral follicles and corpora lutea, relative intra-ovarian abundance of Cyp19a1, Inhba, and Inhbb transcripts, and circulating progesterone levels that all remained similar to those of the CTR group.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  21. 21AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ovarian changes after ganirelix were not associated with increased ovarian aging.

    In plain wordsIn mice, ovarian changes after ganirelix did not accompany increased ovarian aging.

    Peptide
    Ganirelix
    Outcome
    No significant changeOvarian aging
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Aging markers · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    These observed alterations in ovarian function were not associated with increased ovarian aging or inflammation.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…
  22. 22AnimalAnimal study (in vivo)Efficacy outcome

    In mice, ovarian changes after ganirelix were not associated with increased inflammation.

    In plain wordsIn mice, ovarian changes after ganirelix did not accompany increased inflammation.

    Peptide
    Ganirelix
    Outcome
    No significant changeOvarian inflammation
    Study

    mousen: not reported in source

    Swiss female mice
    Comparator
    Vehicle control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    10 µg/mouse daily · injection · between 10 and 16 postnatal daysAs given in this study (mouse).

    Source sentences

    Summary
    These observed alterations in ovarian function were not associated with increased ovarian aging or inflammation.
    1 context sentence
    Summary · context
    To determine the link between gonadotrope axis activity at minipuberty and reproductive parameters, we used a pharmacological approach to suppress gonadotropin levels in Swiss mice by injecting daily a GnRH receptor antagonist (GnRHR) (Ganirelix, 10 µg/mouse) or its vehicle between 10 and 16 postnat…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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