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Study · Measured the body's own peptide · 2024

2 results

Case report: Non-linear evolution of oxytocin informs YBOCS changes post-DBS of the bed nucleus of the stria terminalis for treatment resistant OCD.

Belge JB, Geenen V, Salado AL, Kaschten B, Martin D, Scantamburlo G

Frontiers in psychiatry27 Jan 2025

PMID39931193 (opens in a new tab)PMCIDPMC11807955 (opens in a new tab)DOI10.3389/fpsyt.2024.1473797 (opens in a new tab)PepBankPUB-39931193
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Summary

IntroductionObsessive-compulsive disorder (OCD) is a challenging neuropsychiatric condition with a subset of patients remaining refractory to conventional treatments. Deep brain stimulation (DBS) of the bed nucleus of the stria terminalis (BNST) has shown promise for severe, treatment-resistant OCD. This case report examines the relationship between plasma oxytocin levels and OCD symptom severity following BNST-DBS.MethodsA 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST. Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years. Longitudinal and correlational analyses were performed using linear and polynomial regression models.ResultsNon-linear trends in oxytocin levels were identified, with polynomial regression revealing a significant quadratic term, suggesting a parabolic trend. Strong positive correlations were found between changes in oxytocin levels and YBOCS total, obsession, and compulsion scores.ConclusionThe findings suggest a significant non-linear evolution of oxytocin levels and a positive correlation with OCD symptom changes following BNST-DBS. Oxytocin levels could serve as a biomarker for DBS efficacy if this finding is replicated in larger studies.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelCase report or seriesOther

    In one patient with treatment-resistant OCD, plasma oxytocin followed a non-linear, parabolic course after deep brain stimulation of the bed nucleus of the stria terminalis.

    In plain wordsIn one patient with OCD, the body's own oxytocin level rose and fell in a curve after deep brain stimulation.

    Peptide
    Oxytocin
    Outcome
    MixedLongitudinal course of plasma oxytocin after BNST-DBS
    Study

    n = 1

    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    Non-linear trends in oxytocin levels were identified, with polynomial regression revealing a significant quadratic term, suggesting a parabolic trend.
    2 context sentences
    Summary · context
    A 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST.
    Summary · context
    Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelCase report or seriesOther

    In one patient with treatment-resistant OCD after deep brain stimulation, changes in plasma oxytocin correlated strongly and positively with changes in YBOCS total, obsession and compulsion scores.

    In plain wordsIn one patient with OCD, changes in the body's own oxytocin level were linked to changes in OCD symptom scores.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of plasma oxytocin change with YBOCS scores
    Study

    n = 1

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    Strong positive correlations were found between changes in oxytocin levels and YBOCS total, obsession, and compulsion scores.
    2 context sentences
    Summary · context
    A 36-year-old patient with long-standing, treatment-resistant OCD underwent stereotactic implantation of DBS electrodes at the BNST.
    Summary · context
    Postoperative assessments included OCD symptom severity using the Yale-Brown Obsessive Compulsive Scale (YBOCS) and plasma oxytocin levels, measured at 12 time points over three years.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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