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Study · Animal study (in vivo) · macaca mulatta · 2025

2 results

Influence of Retrodipeptide Analogue of Cholecystokinin Tetrapeptide (GB-115) and Phenazepam on the Behavior of Rhesus Monkeys under Isolation Conditions.

Panchenko AV, Panchenko AV, Pavlova LE, Timina MF, Cherkashina EV, Kolik LG, Seredenin SB

Doklady. Biochemistry and biophysics22 Jan 2025

PMID39847298 (opens in a new tab)DOI10.1134/s1607672924701254 (opens in a new tab)PepBankPUB-39847298
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, GB‑115 reduced time in the upper cage compared with the background period.

    In plain wordsIn rhesus monkeys, GB‑115 reduced time in the upper cage compared with the background period.

    Peptide
    GB-115
    Outcome
    DecreaseTime in upper cage
    Study

    Macaca mulattan = 4

    male rhesus monkeys under individual caging
    Comparator
    Background period
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.001 g · oralAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    GB-115 (0.001 g each) and phenazepam (0.001 g each) decreased the stay of the animals in the upper part of the cage compared to the background period, indicating decrease in stress response.
    2 context sentences
    Summary · context
    The study was conducted on four male rhesus monkeys (Macaca mulatta) aged 5.7-6.7 years.
    Summary · context
    Both drugs were administered one at a time (7 days) and then two tablets each (7 days).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rhesus monkeys, GB‑115 reduced the cortisol/DHEA-S ratio.

    In plain wordsIn rhesus monkeys, GB‑115 reduced the cortisol/DHEA-S ratio.

    Peptide
    GB-115
    Outcome
    DecreaseCortisol/DHEA-S ratio
    Study

    Macaca mulattan = 4

    male rhesus monkeys under individual caging
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    0.002 g · oralAs given in this study (Macaca mulatta).

    Source sentences

    Summary
    GB-115 (0.002 g each) reduced the cortisol/DHEA-S ratio.
    2 context sentences
    Summary · context
    The study was conducted on four male rhesus monkeys (Macaca mulatta) aged 5.7-6.7 years.
    Summary · context
    Both drugs were administered one at a time (7 days) and then two tablets each (7 days).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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