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Study · Systematic review · 2025

2 results

Effects of oxytocin administration on non-social executive functions in humans: a preregistered systematic review and meta-analysis.

Kang H, Glaser BD, Sartorius AI, Audunsdottir K, Kildal ES, Nærland T, Andreassen OA, Westlye LT, Quintana DS

Molecular psychiatry18 Jan 2025Cited by 6 (Europe PMC)

PMID39827218 (opens in a new tab)DOI10.1038/s41380-024-02871-4 (opens in a new tab)PepBankPUB-39827218
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In humans, a meta-analysis found no overall significant effect of oxytocin administration on non-social executive functions.

    In plain wordsIn people, pooled studies found no overall effect of oxytocin on thinking skills that are not social.

    Peptide
    Oxytocin
    Outcome
    No significant changeOverall non-social executive function
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Hedges' g
    0.07
    overall executive function

    Source sentences

    Summary
    We found no overall significant effect of oxytocin administration on non-social executive functions (p = 0.30; Hedges' g = 0.07).
    1 context sentence
    Summary · context
    We conducted a meta-analysis of 20 effect estimates from 13 eligible studies.
  2. 02HumanSystematic reviewEfficacy outcome

    In humans, a meta-analysis found a significant effect of oxytocin administration on cognitive flexibility (Hedges' g = 0.2, p = 0.02).

    In plain wordsIn people, pooled studies found a small effect of oxytocin on cognitive flexibility.

    Peptide
    Oxytocin
    Outcome
    IncreaseCognitive flexibility
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Hedges' g
    0.2
    cognitive flexibility

    Source sentences

    Summary
    However, effect sizes across sub-categories of executive function varied, where the effect of oxytocin administration was the largest for cognitive flexibility (p = 0.02; Hedges' g = 0.2).
    1 context sentence
    Summary · context
    We conducted a meta-analysis of 20 effect estimates from 13 eligible studies.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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