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Study · Animal study (in vivo) · mouse · 2025

8 results

LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria.

Tang Y, Yang C, Zhao J, Heng H, Peng M, Sun L, Dai L, Chan EW, Chen S

Journal of advanced research9 Jan 2025Cited by 11 (Europe PMC)

PMID39793961 (opens in a new tab)PMCIDPMC12793795 (opens in a new tab)DOI10.1016/j.jare.2024.12.044 (opens in a new tab)PepBankPUB-39793961
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In infected mice, LTX‑315 demonstrated efficacy against multidrug-resistant and hypervirulent Klebsiella pneumoniae.

    In plain wordsIn mice, LTX‑315 showed activity against drug-resistant and highly virulent Klebsiella pneumoniae.

    Peptide
    LTX-315
    Outcome
    Not applicableIn vivo antibacterial efficacy
    Study

    mousen: not reported in source

    multidrug-resistant and hypervirulent Klebsiella pneumoniae infection
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, the efficacy of LTX-315 in vivo against multidrug-resistant and hypervirulent Klebsiella pneumoniae was demonstrated.
    1 context sentence
    Summary · context
    Finally, the efficacy in vivo of LTX-315 against drug-resistant bacteria was proved through amice infection model.
  2. 02LabIn vitro (cells)Activity measurement

    In bacterial assays, LTX‑315 effectively eliminated gram-positive pathogens, including multidrug-resistant strains.

    In plain wordsIn lab tests, LTX‑315 killed gram-positive pathogens, including drug-resistant strains.

    Peptide
    LTX-315
    Outcome
    DecreaseGram-positive pathogen killing
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study, LTX-315, an oncolytic peptide, was discovered to effectively eliminate gram-positive and gram-negative pathogens, even for those multidrug-resistant strains.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  3. 03LabIn vitro (cells)Activity measurement

    In bacterial assays, LTX‑315 effectively eliminated gram-negative pathogens, including multidrug-resistant strains.

    In plain wordsIn lab tests, LTX‑315 killed gram-negative pathogens, including drug-resistant strains.

    Peptide
    LTX-315
    Outcome
    DecreaseGram-negative pathogen killing
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study, LTX-315, an oncolytic peptide, was discovered to effectively eliminate gram-positive and gram-negative pathogens, even for those multidrug-resistant strains.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  4. 04LabIn vitro (cells)Mechanism

    In bacterial assays, LTX‑315 damaged cell membrane integrity.

    In plain wordsIn lab tests, LTX‑315 damaged bacterial membrane integrity.

    Peptide
    LTX-315
    Outcome
    DecreaseMembrane integrity
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, it exerts various impacts on cell membranes, including damaging integrity, increasing permeability, and decreasing membrane fluidity.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  5. 05LabIn vitro (cells)Mechanism

    In bacterial assays, LTX‑315 increased cell membrane permeability.

    In plain wordsIn lab tests, LTX‑315 increased bacterial membrane permeability.

    Peptide
    LTX-315
    Outcome
    IncreaseMembrane permeability
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, it exerts various impacts on cell membranes, including damaging integrity, increasing permeability, and decreasing membrane fluidity.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  6. 06LabIn vitro (cells)Mechanism

    In bacterial assays, LTX‑315 decreased cell membrane fluidity.

    In plain wordsIn lab tests, LTX‑315 decreased bacterial membrane fluidity.

    Peptide
    LTX-315
    Outcome
    DecreaseMembrane fluidity
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, it exerts various impacts on cell membranes, including damaging integrity, increasing permeability, and decreasing membrane fluidity.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  7. 07LabIn vitro (cells)Mechanism

    In bacterial assays, microscopy showed significant cell disintegration with LTX‑315.

    In plain wordsIn lab tests, microscopy showed significant bacterial cell breakdown with LTX‑315.

    Peptide
    LTX-315
    Outcome
    IncreaseCell disintegration
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, microscopy revealed significant cell disintegration.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.
  8. 08LabIn vitro (cells)Mechanism

    In bacterial assays, LTX‑315 increased intracellular reactive oxygen species levels.

    In plain wordsIn lab tests, LTX‑315 increased reactive oxygen species inside bacterial cells.

    Peptide
    LTX-315
    Outcome
    IncreaseReactive oxygen species
    Study

    bacterian: not reported in source

    multidrug-resistant bacterial assays
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The influence, in turn, disrupts several physiological activities inside cells, such as increasing the reactive oxygen species level, ultimately leading to cell death.
    1 context sentence
    Summary · context
    Then, the bactericidal effect and its action mode were explored through biochemical and chemistry methods such as atime-killing curve, scanning electronic microscopy, isothermal titration calorimetry analysis, and nuclear magnetic resonance.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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