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Study · Animal study (in vivo) · rat · 2025

5 results

Abaloparatide Enhances Bone Regeneration in Extraction Socket Dental Implant Defects: An Experimental In Vivo Study.

Latimer J, Yilmaz B, Feher B, Shiba T, Fretwurst T, Mitlak B, Lanske B, Kostenuik P, Giannobile WV

Clinical oral implants research9 Jan 2025Cited by 6 (Europe PMC)

PMID39789749 (opens in a new tab)PMCIDPMC11996603 (opens in a new tab)DOI10.1111/clr.14397 (opens in a new tab)PepBankPUB-39789749
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, abaloparatide increased extraction socket bone volume fraction compared with vehicle.

    In plain wordsIn rats, abaloparatide increased the bone volume fraction in extraction sockets compared with vehicle.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseExtraction socket bone volume fraction
    Study

    Ratn: not reported in source

    Sprague-Dawley tooth extraction and implant defect model
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 μg/kg daily · subcutaneous · 42 daysAs given in this study (Rat).

    Source sentences

    Summary
    Micro-computed tomography (micro-CT) analysis demonstrated that ABL increased bone volume fraction (p = 0.004) and bone mineral density (BMD) (p = 0.006) of regenerated extraction sockets at 42d.
    1 context sentence
    Summary · context
    Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, abaloparatide increased extraction socket BMD compared with vehicle.

    In plain wordsIn rats, abaloparatide increased bone density in extraction sockets compared with vehicle.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseExtraction socket BMD
    Study

    Ratn: not reported in source

    Sprague-Dawley tooth extraction and implant defect model
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 μg/kg daily · subcutaneous · 42 daysAs given in this study (Rat).

    Source sentences

    Summary
    Micro-computed tomography (micro-CT) analysis demonstrated that ABL increased bone volume fraction (p = 0.004) and bone mineral density (BMD) (p = 0.006) of regenerated extraction sockets at 42d.
    1 context sentence
    Summary · context
    Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, abaloparatide increased femur trabecular BMD compared with vehicle after 6, 9, and 14 weeks.

    In plain wordsIn rats, abaloparatide increased femur trabecular bone density compared with vehicle after 6, 9, and 14 weeks.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseFemur trabecular BMD
    Study

    Ratn: not reported in source

    Sprague-Dawley tooth extraction and implant defect model
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 μg/kg daily · subcutaneous · 6, 9, and 14 weeksAs given in this study (Rat).

    Source sentences

    Summary
    Micro-CT of the femur validated systemic effects of ABL, showing greater trabecular BMD after 6 (p < 0.01), 9 (p < 0.001), and 14 (p < 0.001) weeks of treatment.
    1 context sentence
    Summary · context
    Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, abaloparatide increased mineralized bone area in extraction sockets compared with control.

    In plain wordsIn rats, abaloparatide increased mineralized bone area in extraction sockets compared with control.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseExtraction socket mineralized bone area
    Study

    Ratn: not reported in source

    Sprague-Dawley tooth extraction and implant defect model
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 μg/kg daily · subcutaneous · 42 daysAs given in this study (Rat).

    Source sentences

    Summary
    Histomorphometry confirmed a higher mineralized bone area with ABL treatment in extraction sockets at 42d (p = 0.03) and in the regenerated peri-implant bone at 21d post-implant placement (p = 0.01) compared to control.
    1 context sentence
    Summary · context
    Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, abaloparatide increased mineralized peri-implant bone area compared with control.

    In plain wordsIn rats, abaloparatide increased mineralized bone area around implants compared with control.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreasePeri-implant mineralized bone area
    Study

    Ratn: not reported in source

    Sprague-Dawley tooth extraction and implant defect model
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    25 μg/kg daily · subcutaneous · 21 days post-implant placementAs given in this study (Rat).

    Source sentences

    Summary
    Histomorphometry confirmed a higher mineralized bone area with ABL treatment in extraction sockets at 42d (p = 0.03) and in the regenerated peri-implant bone at 21d post-implant placement (p = 0.01) compared to control.
    1 context sentence
    Summary · context
    Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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