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Study · Ex vivo tissue · bovine · 2025

6 results

Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.

Ullah S, Haider Z, Perera CD, Lee SH, Idrees M, Park S, Kong IK

Life sciences7 Jan 2025Cited by 2 (Europe PMC)

PMID39788414 (opens in a new tab)DOI10.1016/j.lfs.2025.123381 (opens in a new tab)PepBankPUB-39788414
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In bovine oocytes matured in vitro, Epitalon treatment increased the oocyte maturation rate compared with the control group (p < 0.05).

    In plain wordsIn cow oocytes in lab culture, Epitalon raised the maturation rate compared with the control group.

    Peptide
    Epitalon
    Outcome
    IncreaseOocyte maturation rate
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Comparator
    Control group
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We observed a significant improvement in the oocyte maturation rate compared with the control group (p < 0.05).
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.
  2. 02LabEx vivo tissueEfficacy outcome

    In post-thawed bovine embryos, Epitalon treatment increased the blastocyst hatching rate (p < 0.05).

    In plain wordsIn thawed cow embryos in lab culture, Epitalon raised the rate at which blastocysts hatched.

    Peptide
    Epitalon
    Outcome
    IncreaseBlastocyst hatching rate of post-thawed embryos
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, telomerase activity was significantly compromised in post-thawed embryos, and Epitalon treatment significantly improved blastocyst hatching rate and implantation potential (p < 0.05).
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.
  3. 03LabEx vivo tissueEfficacy outcome

    In post-thawed bovine embryos, Epitalon treatment increased implantation potential (p < 0.05).

    In plain wordsIn thawed cow embryos in lab culture, Epitalon raised the potential of the embryos to implant.

    Peptide
    Epitalon
    Outcome
    IncreaseImplantation potential of post-thawed embryos
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, telomerase activity was significantly compromised in post-thawed embryos, and Epitalon treatment significantly improved blastocyst hatching rate and implantation potential (p < 0.05).
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.
  4. 04LabEx vivo tissueEfficacy outcome

    In bovine in vitro matured oocytes, Epitalon enhanced oocyte quality and health in qPCR, reactive oxygen species and JC-1 assays.

    In plain wordsIn cow oocytes in lab culture, Epitalon improved measures of oocyte quality and health.

    Peptide
    Epitalon
    Outcome
    IncreaseOocyte quality and health (qPCR, ROS, JC-1)
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we performed qPCR, reactive oxygen species, and JC-1 (ΔΨm) assays to evaluate the effect of Epitalon on the health of in vitro mature oocytes, cumulus cells, and post-thawed blastocysts, and the result showed that Epitalon highly enhances the quality and health of the oocyte, cumulus cell,…
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.
  5. 05LabEx vivo tissueEfficacy outcome

    In bovine cumulus cells, Epitalon enhanced cell quality and health in qPCR, reactive oxygen species and JC-1 assays.

    In plain wordsIn cow cumulus cells in lab culture, Epitalon improved measures of cell quality and health.

    Peptide
    Epitalon
    Outcome
    IncreaseCumulus cell quality and health (qPCR, ROS, JC-1)
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we performed qPCR, reactive oxygen species, and JC-1 (ΔΨm) assays to evaluate the effect of Epitalon on the health of in vitro mature oocytes, cumulus cells, and post-thawed blastocysts, and the result showed that Epitalon highly enhances the quality and health of the oocyte, cumulus cell,…
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.
  6. 06LabEx vivo tissueEfficacy outcome

    In post-thawed bovine blastocysts, Epitalon enhanced quality and health in qPCR, reactive oxygen species and JC-1 assays.

    In plain wordsIn thawed cow blastocysts in lab culture, Epitalon improved measures of embryo quality and health.

    Peptide
    Epitalon
    Outcome
    IncreasePost-thawed blastocyst quality and health (qPCR, ROS, JC-1)
    Study

    bovinen: not reported in source

    Bovine cumulus-oocyte complexes, oocytes and embryos in vitro
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, we performed qPCR, reactive oxygen species, and JC-1 (ΔΨm) assays to evaluate the effect of Epitalon on the health of in vitro mature oocytes, cumulus cells, and post-thawed blastocysts, and the result showed that Epitalon highly enhances the quality and health of the oocyte, cumulus cell,…
    1 context sentence
    Summary · context
    We activated telomerase via Epitalon, a tetrapeptide with the amino acid sequence Ala-Glut-Asp-Gly.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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