Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.

Wang Z, Liu J, Chen Q, Wu Y, Li Y, Ou M, Tang S, Deng Z, Liu L, Jiang C, Zhu H, Liu Q, Yang B

Advanced science (Weinheim, Baden-Wurttemberg, Germany)9 Jan 2025Cited by 23 (Europe PMC)

PMID39783908PMCIDPMC11848569DOI10.1002/advs.202412581PepBankPUB-39783908

Summary

Sigal peptides have garnered remarkable efficacy in rejuvenating photoaged skin and delaying senescence. Nevertheless, their low solubility and poor permeability bring about a formidable challenge in their transdermal delivery. To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared. The components ratios and inherent forming mechanisms of GA-OMT (GAO) are optimized by molecular dynamics simulations and density functional theory calculations. Remarkably, GAO can significantly improve the sparingly soluble properties of palmitoyl pentapeptide-4 (PAL-4), a model peptide drug. Subsequently, GAO self-assembled micelles loading PAL-4 (GAO/PAL-4-SM) are fabricated without additional auxiliary materials. The permeation and subcutaneous retention of PAL-4 are significantly promoted with 10wt.% GAO-SM. Moreover, GAO ILs facilitated PAL-4 permeation by enhancing its miscibility and interaction with stratum corneum (SC), offering a pulling effect and micellar structures for PAL-4, as elucidated by computational simulations. In cellular and animal photoaging experiments, GAO/PAL-4-SM possessed remarkable capabilities in boosting collagen and hyaluronic acid regeneration, mitigating inflammation and apoptosis, accelerating macrophage M2 polarization, thereby lessening skin wrinkles and leveraging elasticity. Collectively, the research innovatively designed an ILs self-assembled nano-micellar transdermal delivery system to enhance the permeability and anti-photoaging effect of signal peptides.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

01AnimalNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneOther designEfficacy outcome
In pooled cellular and animal experiments, GAO/PAL-4 micelles showed regenerative, anti-inflammatory, antiapoptotic, macrophage-polarizing, and skin improvements.
In plain wordsIn cellular and animal experiments, GAO/PAL-4 micelles showed several reported skin repair effects.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
MixedPhotoaging response across cellular and animal experiments
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In cellular and animal photoaging experiments, GAO/PAL-4-SM possessed remarkable capabilities in boosting collagen and hyaluronic acid regeneration, mitigating inflammation and apoptosis, accelerating macrophage M2 polarization, thereby lessening skin wrinkles and leveraging elasticity.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Show in the study text Report a problemFND-3978390805
02LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cell-free)Activity measurement
In formulation tests, glycyrrhizic acid-oxymatrine ionic liquids improved palmitoyl pentapeptide-4 solubility.
In plain wordsIn lab tests, glycyrrhizic acid-oxymatrine liquids improved palmitoyl pentapeptide-4 solubility.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePAL-4 solubility
Study
n: not reported in source
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
Remarkably, GAO can significantly improve the sparingly soluble properties of palmitoyl pentapeptide-4 (PAL-4), a model peptide drug.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Show in the study text Report a problemFND-3978390801
03LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneOther designPharmacokinetics
In skin delivery tests, GAO micelles promoted palmitoyl pentapeptide-4 permeation.
In plain wordsIn lab tests, GAO micelles increased palmitoyl pentapeptide-4 passage through skin.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePAL-4 permeation
Study
n: not reported in source
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
The permeation and subcutaneous retention of PAL-4 are significantly promoted with 10wt.% GAO-SM.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Show in the study text Report a problemFND-3978390802
04LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneOther designPharmacokinetics
In skin delivery tests, GAO micelles promoted subcutaneous retention of palmitoyl pentapeptide-4.
In plain wordsIn lab tests, GAO micelles increased palmitoyl pentapeptide-4 retention beneath the skin.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreasePAL-4 subcutaneous retention
Study
n: not reported in source
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
The permeation and subcutaneous retention of PAL-4 are significantly promoted with 10wt.% GAO-SM.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Show in the study text Report a problemFND-3978390803
05Computer modelNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn silicoMechanism
In simulations, GAO facilitated palmitoyl pentapeptide-4 permeation through improved stratum corneum interactions and micellar structures.
In plain wordsIn computer models, GAO helped palmitoyl pentapeptide-4 permeate through interactions with the skin barrier and micellar structures.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
IncreaseSimulated permeation mechanism
Study
n: not reported in source
Outcome group
Pharmacokinetics · Skin and wound
Source sentences
Summary
Moreover, GAO ILs facilitated PAL-4 permeation by enhancing its miscibility and interaction with stratum corneum (SC), offering a pulling effect and micellar structures for PAL-4, as elucidated by computational simulations.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this challenge, bioactive ionic liquids (ILs) synthesized from natural glycyrrhizic acid (GA) and oxymatrine (OMT) with eminent biocompatibility is first prepared.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Show in the study text Report a problemFND-3978390804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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