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Study · Measured the body's own peptide · 2025

4 results

Endurance training enhances skeletal muscle mitochondrial respiration by promoting MOTS-c secretion.

Feng Y, Rao Z, Tian X, Hu Y, Yue L, Meng Y, Zhong Q, Chen W, Xu W, Li H, Hu Y, Shi R

Free radical biology & medicine18 Dec 2024Cited by 11 (Europe PMC)

PMID39706498 (opens in a new tab)DOI10.1016/j.freeradbiomed.2024.12.038 (opens in a new tab)PepBankPUB-39706498
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In marathon runners, sedentary subjects and mice, serum MOTS‑c levels were closely associated with aerobic exercise capacity.

    In plain wordsIn runners, sedentary people and mice, the body's own MOTS‑c levels were linked to aerobic fitness.

    Peptide
    MOTS-c
    Outcome
    Not applicableAssociation of serum MOTS-c with aerobic exercise capacity
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Whole body

    Source sentences

    Summary
    Our results indicated a close association between serum MOTS-c levels and aerobic exercise capacity.
    2 context sentences
    Summary · context
    Here, we tested indices such as maximal oxygen uptake and serum MOTS-c levels in marathon runners and sedentary subjects.
    Summary · context
    In addition, we tested aerobic exercise capacity, skeletal muscle mitochondrial respiration rate, and serum MOTS-c levels in mice subjected to long-term endurance training groups and sedentary groups.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In mice, long-term endurance training may promote secretion of the body's own MOTS‑c, compared with sedentary mice.

    In plain wordsIn mice, long-term endurance training may raise the body's own MOTS‑c, compared with sedentary mice.

    Peptide
    MOTS-c
    Outcome
    IncreaseSerum MOTS-c secretion after endurance training
    Study

    mousen: not reported in source

    Comparator
    Sedentary mice
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c
    2 context sentences
    Summary · context
    Here, we tested indices such as maximal oxygen uptake and serum MOTS-c levels in marathon runners and sedentary subjects.
    Summary · context
    In addition, we tested aerobic exercise capacity, skeletal muscle mitochondrial respiration rate, and serum MOTS-c levels in mice subjected to long-term endurance training groups and sedentary groups.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice, endurance training was linked to activation of the AMPK/PGC-1α pathway alongside MOTS‑c secretion.

    In plain wordsIn mice, endurance training was linked to activation of an energy-related pathway along with more of the body's own MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseAMPK/PGC-1α pathway activation by endurance training
    Study

    mousen: not reported in source

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle by promoting the secretion of MOTS-c and activating the AMPK/PGC-1α pathway
    2 context sentences
    Summary · context
    Here, we tested indices such as maximal oxygen uptake and serum MOTS-c levels in marathon runners and sedentary subjects.
    Summary · context
    In addition, we tested aerobic exercise capacity, skeletal muscle mitochondrial respiration rate, and serum MOTS-c levels in mice subjected to long-term endurance training groups and sedentary groups.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

  1. 04AnimalNot a test of MOTS-c aloneAnimal study (in vivo)Efficacy outcome

    In mice, endurance training may enhance the mitochondrial respiratory function of skeletal muscle.

    In plain wordsIn mice, endurance training may improve how muscle mitochondria use oxygen. Nobody gave MOTS‑c.

    Peptide
    MOTS-c
    Outcome
    IncreaseSkeletal muscle mitochondrial respiratory function after endurance training
    Study

    mousen: not reported in source

    Comparator
    Sedentary mice
    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    we found that endurance training may enhance the mitochondrial respiratory function of skeletal muscle
    2 context sentences
    Summary · context
    Here, we tested indices such as maximal oxygen uptake and serum MOTS-c levels in marathon runners and sedentary subjects.
    Summary · context
    In addition, we tested aerobic exercise capacity, skeletal muscle mitochondrial respiration rate, and serum MOTS-c levels in mice subjected to long-term endurance training groups and sedentary groups.

    In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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