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Study · Ex vivo tissue · 2024

5 results

Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries.

Edvinsson JCA, Grubor I, Maddahi A, Edvinsson L

The journal of headache and pain11 Dec 2024Cited by 5 (Europe PMC)

PMID39663536 (opens in a new tab)PMCIDPMC11633024 (opens in a new tab)DOI10.1186/s10194-024-01933-w (opens in a new tab)PepBankPUB-39663536
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Summary

BackgroundThe purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localization of hormones and neuropeptides with relevance to migraine (vasopressin, oxytocin, estrogen, progesterone, testosterone, amylin, adrenomedullin and calcitonin gene-related peptide (CGRP)) in human intracranial arteries.MethodsHuman cortical cerebral and middle meningeal arteries were used in this study. The tissues were removed in conjunction with neurosurgery and donated with consent. Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph. Immunohistochemistry was performed to examine the expression and localization of their receptors within human intracranial arteries.ResultsVasopressin showed the strongest contractile responses, followed by oxytocin and progesterone. CGRP displayed the strongest vasodilatory response when compared to adrenomedullin, amylin, testosterone and estrogen. No significant differences were observed in vasomotor responses between male and female arteries. The vasomotor effects were supported by the presence of corresponding receptors in the vascular smooth muscle cells. Estrogen receptors (ERα and ERβ), progesterone receptor (PR), vasopressin 1a receptor (V1aR), and the oxytocin receptor (OTR) were expressed in the walls of both cerebral arteries overlying the cerebral cortex and intracranial arteries of the dura mater. ERα, V1aR, and PR were found to be localized in both smooth muscle cells and endothelium, whereas OTR was exclusively located within the smooth muscle cells.ConclusionsHypothalamic, sex hormones and the pancreas hormone (amylin) receptors are expressed in the human intracranial artery walls. The vasomotor responses revealed no sex differences, however contractile responses to vasopressin was higher and more potent in MMA compared to CCA when pooling data from both sexes. Overall, the hormones estrogen, progesterone and oxytocin, which drop in circulating levels at onset of menstruation, only showed modest vasomotor responses as compared to CGRP. This suggests that their role in inducing menstrual migraine attacks is not directly related to vasomotor responses.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In isolated human intracranial arteries, oxytocin caused contractile responses, weaker than vasopressin and stronger than progesterone.

    In plain wordsIn lab tests on human brain arteries, oxytocin made the arteries contract, less than vasopressin did and more than progesterone did.

    Peptide
    Oxytocin
    Outcome
    IncreaseContractile response of human intracranial arteries to oxytocin
    Study

    humann: not reported in source

    Isolated human cortical cerebral and middle meningeal arteries (wire myograph)
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vasopressin showed the strongest contractile responses, followed by oxytocin and progesterone.
    2 context sentences
    Summary · context
    Human cortical cerebral and middle meningeal arteries were used in this study.
    Summary · context
    Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In isolated human intracranial arteries, estrogen, progesterone and oxytocin together showed only modest vasomotor responses compared with CGRP.

    In plain wordsIn lab tests on human brain arteries, estrogen, progesterone and oxytocin together caused only modest responses compared with CGRP.

    Peptide
    Oxytocin
    Outcome
    Not applicableVasomotor responses to estrogen, progesterone and oxytocin compared with CGRP
    Study

    humann: not reported in source

    Isolated human cortical cerebral and middle meningeal arteries (wire myograph)
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    Overall, the hormones estrogen, progesterone and oxytocin, which drop in circulating levels at onset of menstruation, only showed modest vasomotor responses as compared to CGRP.
    2 context sentences
    Summary · context
    Human cortical cerebral and middle meningeal arteries were used in this study.
    Summary · context
    Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 03LabNot a test of Oxytocin aloneEx vivo tissueActivity measurement

    In isolated human intracranial arteries, vasomotor responses to the tested hormones and neuropeptides did not differ between male and female arteries.

    In plain wordsIn lab tests on human brain arteries, responses to the tested hormones did not differ between male and female arteries.

    Peptide
    Oxytocin
    Outcome
    No significant changeSex difference in vasomotor responses to hormones and neuropeptides
    Study

    humann: not reported in source

    Isolated human cortical cerebral and middle meningeal arteries (wire myograph)
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    No significant differences were observed in vasomotor responses between male and female arteries.
    2 context sentences
    Summary · context
    Human cortical cerebral and middle meningeal arteries were used in this study.
    Summary · context
    Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    The oxytocin receptor was expressed in the walls of human cerebral arteries and dura mater arteries.

    In plain wordsIn lab tests on human brain arteries, the oxytocin receptor was present in the artery walls.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor expression in intracranial artery walls
    Study

    humann: not reported in source

    Isolated human cortical cerebral and middle meningeal arteries (wire myograph)
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    the oxytocin receptor (OTR) were expressed in the walls of both cerebral arteries overlying the cerebral cortex and intracranial arteries of the dura mater.
    2 context sentences
    Summary · context
    Human cortical cerebral and middle meningeal arteries were used in this study.
    Summary · context
    Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  4. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In human intracranial arteries, the oxytocin receptor was located only within smooth muscle cells.

    In plain wordsIn lab tests on human brain arteries, the oxytocin receptor was found only in smooth muscle cells.

    Peptide
    Oxytocin
    Outcome
    Not applicableLocalization of oxytocin receptor in intracranial arteries
    Study

    humann: not reported in source

    Isolated human cortical cerebral and middle meningeal arteries (wire myograph)
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    whereas OTR was exclusively located within the smooth muscle cells.
    2 context sentences
    Summary · context
    Human cortical cerebral and middle meningeal arteries were used in this study.
    Summary · context
    Vasomotor responses of arteries, after exposure to hormones or neuropeptides, were recorded using a wire myograph.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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