Synergistic-like decreases in alcohol intake following combined pharmacotherapy with GLP-1 and amylin in male rats.

Aranäs C, Caffrey A, Edvardsson CE, Vestlund J, Schmidt HD, Jerlhag E

British journal of pharmacology2 Dec 2024Cited by 6 (Europe PMC)

PMID39622492DOI10.1111/bph.17406PepBankPUB-39622492

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dulaglutide (Trulicity).

01AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In male rats, acute dulaglutide plus salmon calcitonin reduced alcohol intake.
In plain wordsIn male rats, the dulaglutide and salmon calcitonin combination reduced alcohol intake.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseAcute combination alcohol intake in males
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Appetite and food intake · Mental health and mood
Source sentences
Summary
Acute administration of dulaglutide and sCT (0.1 mg·kg^-1 + 5 μg·kg^-1) reduced alcohol intake in males, but not in females.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249201
02AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In female rats, the same acute dulaglutide plus salmon calcitonin combination did not reduce alcohol intake.
In plain wordsIn female rats, the same dulaglutide and salmon calcitonin combination did not reduce alcohol intake.
Peptide
Dulaglutide (Trulicity)
Outcome
No significant changeAcute combination alcohol intake in females
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Appetite and food intake · Mental health and mood
Source sentences
Summary
Acute administration of dulaglutide and sCT (0.1 mg·kg^-1 + 5 μg·kg^-1) reduced alcohol intake in males, but not in females.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249202
03AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In female rats, higher doses of the dulaglutide and salmon calcitonin combination decreased alcohol intake.
In plain wordsIn female rats, higher doses of the dulaglutide and salmon calcitonin combination lowered alcohol intake.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseHigher-dose combination alcohol intake in females
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Appetite and food intake · Mental health and mood
Source sentences
Summary
When higher doses were evaluated in female rats, a decrease in alcohol intake was observed.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249203
04AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In male rats, low-dose dulaglutide plus salmon calcitonin decreased alcohol intake in a synergistic-like manner.
In plain wordsIn male rats, low-dose dulaglutide plus salmon calcitonin lowered alcohol intake in a synergistic-like manner.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseLow-dose combination alcohol intake in males
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Appetite and food intake · Mental health and mood
Source sentences
Summary
Furthermore, the low dose combination (0.075 mg·kg^-1 + 2 μg·kg^-1) decreased, in in a synergistic-like manner, alcohol intake and prevented abstinence-induced drinking without affecting kaolin intake in males.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249204
05AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In male rats, low-dose dulaglutide plus salmon calcitonin prevented abstinence-induced drinking.
In plain wordsIn male rats, low-dose dulaglutide plus salmon calcitonin prevented drinking induced by abstinence.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseAbstinence-induced drinking
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Appetite and food intake · Mental health and mood
Source sentences
Summary
Furthermore, the low dose combination (0.075 mg·kg^-1 + 2 μg·kg^-1) decreased, in in a synergistic-like manner, alcohol intake and prevented abstinence-induced drinking without affecting kaolin intake in males.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249205
06AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Safety outcome
In male rats, low-dose dulaglutide plus salmon calcitonin did not affect kaolin intake.
In plain wordsIn male rats, low-dose dulaglutide plus salmon calcitonin did not change kaolin intake.
Peptide
Dulaglutide (Trulicity)
Outcome
No significant changeKaolin intake
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Adverse events · Gastrointestinal
Source sentences
Summary
Furthermore, the low dose combination (0.075 mg·kg^-1 + 2 μg·kg^-1) decreased, in in a synergistic-like manner, alcohol intake and prevented abstinence-induced drinking without affecting kaolin intake in males.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249206
07AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Efficacy outcome
In rats, tolerance developed during sub-chronic dulaglutide plus salmon calcitonin treatment.
In plain wordsIn rats, tolerance developed during repeated dulaglutide plus salmon calcitonin treatment.
Peptide
Dulaglutide (Trulicity)
Outcome
Not applicableTolerance to combination treatment
Study
ratn: not reported in source
Alcohol intake in male and female rats
Outcome group
Drug tolerance · Mental health and mood
Source sentences
Summary
However, tolerance developed during sub-chronic treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Furthermore, the low dose combination (0.075 mg·kg^-1 + 2 μg·kg^-1) decreased, in in a synergistic-like manner, alcohol intake and prevented abstinence-induced drinking without affecting kaolin intake in males.
Summary · context
Effects of a range of dose-combinations of GLP-1 receptor (dulaglutide) and amylin receptor (salmon calcitonin; sCT) agonists on alcohol intake were explored in male and female rats.
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3962249207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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