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Study · Measured the body's own peptide · 2025

3 results

The oxytocin system in patients with craniopharyngioma: A systematic review.

Mann A, Kalitsi J, Jani K, Martins D, Kapoor RR, Paloyelis Y

Frontiers in neuroendocrinology30 Nov 2024Cited by 6 (Europe PMC)

PMID39622476 (opens in a new tab)PMCIDPMC11904121 (opens in a new tab)DOI10.1016/j.yfrne.2024.101170 (opens in a new tab)PepBankPUB-39622476
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Summary

Craniopharyngioma is a benign tumour affecting the hypothalamic and pituitary regions, which are involved in the production and secretion of oxytocin. We conducted a systematic review to assess dysregulation of the oxytocin system in craniopharyngioma and associations with neurobehavioural, eating, and metabolic abnormalities. Eight studies (n = 72 patients) were included. Evidence for dysfunction of the endogenous oxytocin system in craniopharyngioma is limited and mixed. While no significant differences in baseline salivary oxytocin concentrations were reported between patients with craniopharyngioma and controls, patients with craniopharyngioma were found to have blunted salivary oxytocin response following exercise stimulation and this was associated with greater state anxiety and higher BMI. Studies administering exogenous oxytocin are sparse and do not meet required standards. Hypothalamic damage may pose an additional mechanism of oxytocin dysregulation. Improving understanding of the oxytocin system in craniopharyngioma could be pivotal for exploring the potential therapeutic role of exogenous oxytocin in this condition.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelSystematic reviewOther

    In patients with craniopharyngioma, baseline salivary levels of the body's own oxytocin did not differ significantly from controls.

    In plain wordsIn people with craniopharyngioma, the body's own oxytocin in saliva at baseline was not different from controls.

    Peptide
    Oxytocin
    Outcome
    No significant changeBaseline salivary oxytocin concentration
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    no significant differences in baseline salivary oxytocin concentrations were reported between patients with craniopharyngioma and controls
    1 context sentence
    Summary · context
    Eight studies (n = 72 patients) were included.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelSystematic reviewOther

    In patients with craniopharyngioma, the salivary oxytocin response to exercise stimulation was blunted compared with controls.

    In plain wordsIn people with craniopharyngioma, the body's own oxytocin rose less after exercise than in controls.

    Peptide
    Oxytocin
    Outcome
    DecreaseSalivary oxytocin response to exercise stimulation
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    patients with craniopharyngioma were found to have blunted salivary oxytocin response following exercise stimulation
    1 context sentence
    Summary · context
    Eight studies (n = 72 patients) were included.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelSystematic reviewOther

    In patients with craniopharyngioma, the blunted salivary oxytocin response was associated with greater state anxiety and higher BMI.

    In plain wordsIn people with craniopharyngioma, a smaller rise in the body's own oxytocin was linked to more anxiety and higher BMI.

    Peptide
    Oxytocin
    Outcome
    Not applicableBlunted oxytocin response with state anxiety and BMI
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    this was associated with greater state anxiety and higher BMI
    1 context sentence
    Summary · context
    Eight studies (n = 72 patients) were included.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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