MOTS-c regulates the ROS/TXNIP/NLRP3 pathway to alleviate diabetic cardiomyopathy.

Fu Y, Tang M, Duan Y, Pan Y, Liang M, Yuan J, Wang M, Laher I, Li S

Biochemical and biophysical research communications28 Nov 2024Cited by 8 (Europe PMC)

PMID39616938DOI10.1016/j.bbrc.2024.151072PepBankPUB-39616938

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In diabetic rats, MOTS‑c treatment for 8 weeks reduced expression of ROS/TXNIP/NLRP3 pathway proteins.
In plain wordsIn rats with diabetes, MOTS‑c lowered the levels of proteins in an inflammation pathway in the heart.
Peptide
MOTS-c
Outcome
DecreaseROS/TXNIP/NLRP3 pathway protein expression
Study
ratn: not reported in source
Diabetic rats (high-sugar-fat diet plus low-dose streptozotocin)
Outcome group
Inflammation markers · Cardiovascular
Studied dose
0.5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (rat).
Source sentences
Summary
Furthermore, treatment with MOTS-c (0.5 mg/kg/day, i.p.) for 8 weeks reduced the expression of ROS/TXNIP/NLRP3 pathway proteins to inhibit the diabetic myocardial inflammatory response.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the impact of MOTS-c on cardiac structure and inflammation in diabetic rats induced by a high-sugar-fat diet combined with low-dose streptozotocin (30 mg/kg, i.p.).
Report a problemFND-3961693801
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, MOTS‑c treatment for 8 weeks inhibited the diabetic myocardial inflammatory response.
In plain wordsIn rats with diabetes, MOTS‑c reduced heart muscle inflammation.
Peptide
MOTS-c
Outcome
DecreaseDiabetic myocardial inflammatory response
Study
ratn: not reported in source
Diabetic rats (high-sugar-fat diet plus low-dose streptozotocin)
Outcome group
Inflammation markers · Cardiovascular
Studied dose
0.5 mg/kg/day · intraperitoneal · 8 weeksAs given in this study (rat).
Source sentences
Summary
Furthermore, treatment with MOTS-c (0.5 mg/kg/day, i.p.) for 8 weeks reduced the expression of ROS/TXNIP/NLRP3 pathway proteins to inhibit the diabetic myocardial inflammatory response.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the impact of MOTS-c on cardiac structure and inflammation in diabetic rats induced by a high-sugar-fat diet combined with low-dose streptozotocin (30 mg/kg, i.p.).
Report a problemFND-3961693802

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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