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Study · Randomized controlled trial · 2025

3 results

Maternal care is associated with neural and behavioral effects of oxytocin administration during empathic accuracy in schizophrenia and controls.

Brown CK, De Coster L, Lee J, Lin L, Mathalon DH, Woolley JD

Psychoneuroendocrinology8 Nov 2024Cited by 4 (Europe PMC)

PMID39581167 (opens in a new tab)PMCIDPMC11833772 (opens in a new tab)DOI10.1016/j.psyneuen.2024.107228 (opens in a new tab)PepBankPUB-39581167
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia and controls, oxytocin administration did not improve empathic accuracy versus placebo.

    In plain wordsIn adults with schizophrenia and in controls, oxytocin did not improve empathic accuracy compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmpathic accuracy
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin administration was not associated with improved empathic accuracy for either group.
    1 context sentence
    Summary · context
    Using a cross-over, double-blind, placebo-controlled design coupled with fMRI, the current study investigated whether administration of oxytocin improves empathic accuracy in schizophrenia compared to a matched placebo, and the moderating role of early maternal care.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia and controls, higher reported maternal care was linked to the greatest improvement in empathic accuracy with oxytocin versus placebo.

    In plain wordsIn adults with schizophrenia and in controls, people who reported higher maternal care improved most on empathic accuracy with oxytocin, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmpathic accuracy change with oxytocin by maternal care
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in both groups, individuals reporting higher maternal care demonstrated the greatest improvements in empathic accuracy with oxytocin administration
    1 context sentence
    Summary · context
    Using a cross-over, double-blind, placebo-controlled design coupled with fMRI, the current study investigated whether administration of oxytocin improves empathic accuracy in schizophrenia compared to a matched placebo, and the moderating role of early maternal care.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with schizophrenia and controls reporting higher maternal care, oxytocin was accompanied by decreased right dorsolateral prefrontal cortex activity.

    In plain wordsIn adults with schizophrenia and in controls with higher maternal care, oxytocin came with lower activity in one brain region.

    Peptide
    Oxytocin
    Outcome
    DecreaseRight dorsolateral prefrontal cortex activity by maternal care
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    accompanied by decreased activity in the right dorsolateral prefrontal cortex, a region implicated in selective attention to socioemotional stimuli
    1 context sentence
    Summary · context
    Using a cross-over, double-blind, placebo-controlled design coupled with fMRI, the current study investigated whether administration of oxytocin improves empathic accuracy in schizophrenia compared to a matched placebo, and the moderating role of early maternal care.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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