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Study · Animal study (in vivo) · rat · 2024

5 results

Cerebrolysin Induces Motor Recovery Along with Plastic Changes in Motoneurons and an Increase in GAP43 Protein in the Ventral Spinal Cord Following a Kainic Acid Excitotoxic Lesion in the Rat Motor Cortex.

Martínez-Torres NI, Cárdenas-Bedoya J, Torres-Mendoza BM

Neurochemical research24 Nov 2024Cited by 3 (Europe PMC)

PMID39580783 (opens in a new tab)DOI10.1007/s11064-024-04288-5 (opens in a new tab)PepBankPUB-39580783
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with motor cortex lesions, cerebrolysin improved motor activity on the BBB scale.

    In plain wordsIn rats with motor cortex lesions, cerebrolysin improved motor activity on the BBB scale.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBBB motor activity
    Study

    ratn = 27

    Kainic acid lesion of motor cortex
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin administration improved motor activity according to the BBB and Bederson scales, along with increased dendritic intersections and dendritic spine density on motoneurons.
    1 context sentence
    Summary · context
    Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the "Basso, Beattie, and Bresnahan" (BBB) and Bederson scores.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with motor cortex lesions, cerebrolysin improved motor activity on the Bederson scale.

    In plain wordsIn rats with motor cortex lesions, cerebrolysin improved motor activity on the Bederson scale.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBederson motor activity
    Study

    ratn = 27

    Kainic acid lesion of motor cortex
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin administration improved motor activity according to the BBB and Bederson scales, along with increased dendritic intersections and dendritic spine density on motoneurons.
    1 context sentence
    Summary · context
    Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the "Basso, Beattie, and Bresnahan" (BBB) and Bederson scores.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with motor cortex lesions, cerebrolysin increased motoneuron dendritic intersections.

    In plain wordsIn rats with motor cortex lesions, cerebrolysin increased motoneuron dendritic intersections.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDendritic intersections
    Study

    ratn = 27

    Kainic acid lesion of motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin administration improved motor activity according to the BBB and Bederson scales, along with increased dendritic intersections and dendritic spine density on motoneurons.
    1 context sentence
    Summary · context
    Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the "Basso, Beattie, and Bresnahan" (BBB) and Bederson scores.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with motor cortex lesions, cerebrolysin increased motoneuron dendritic spine density.

    In plain wordsIn rats with motor cortex lesions, cerebrolysin increased motoneuron dendritic spine density.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDendritic spine density
    Study

    ratn = 27

    Kainic acid lesion of motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin administration improved motor activity according to the BBB and Bederson scales, along with increased dendritic intersections and dendritic spine density on motoneurons.
    1 context sentence
    Summary · context
    Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the "Basso, Beattie, and Bresnahan" (BBB) and Bederson scores.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with motor cortex lesions, cerebrolysin significantly increased GAP43 protein.

    In plain wordsIn rats with motor cortex lesions, cerebrolysin increased GAP43 protein.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseGAP43 protein
    Study

    ratn = 27

    Kainic acid lesion of motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There was also a significant increase in GAP43 protein, suggesting that CBL may promote plastic changes through this protein, among others.
    1 context sentence
    Summary · context
    Ten days after the KA lesion of the motor cortex, rats were administered cerebrolysin, and their motor performance was evaluated using the "Basso, Beattie, and Bresnahan" (BBB) and Bederson scores.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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