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Study · Measured the body's own peptide · 2024

3 results

Comparison of endogenous hypothalamic and serum OT levels between young and middle-aged perimenopausal female rats.

Masaki R, Yamamoto Y, Tamura K, Aoki H, Noguchi H, Takeda A, Minato S, Tanano R, Yamanaka E, Maeda T, Sugimoto T, Sasada H and 8 more

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Inui H, Kagawa T, Yoshida A, Mineda A, Kinouchi R, Yoshida K, Kaji T, Iwasa T

The journal of medical investigation : JMI1 Jan 2024Cited by 2 (Europe PMC)

PMID39462559 (opens in a new tab)DOI10.2152/jmi.71.246 (opens in a new tab)PepBankPUB-39462559
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, serum oxytocin levels did not differ significantly between middle-aged perimenopausal rats and young rats.

    In plain wordsIn rats, the body's own blood oxytocin levels did not differ significantly between middle-aged and young females.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin level
    Study

    ratn: not reported in source

    Young and middle-aged perimenopausal female rats
    Comparator
    Young rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Although no significant differences were observed in serum OT and E2 levels
    1 context sentence
    Summary · context
    Therefore, we herein compared endogenous levels of hypothalamic and serum OT between young and middle-aged perimenopausal female rats and examined the relationship between serum estrogen and leptin levels.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, hypothalamic oxytocin mRNA levels were significantly higher in middle-aged perimenopausal rats than in young rats.

    In plain wordsIn rats, the body's own oxytocin gene activity in the brain was higher in middle-aged females than in young ones.

    Peptide
    Oxytocin
    Outcome
    IncreaseHypothalamic oxytocin mRNA level
    Study

    ratn: not reported in source

    Young and middle-aged perimenopausal female rats
    Comparator
    Young rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    hypothalamic mRNA levels of OT and the OT receptor (OTR) were significantly higher in middle-aged rats than in young rats
    1 context sentence
    Summary · context
    Therefore, we herein compared endogenous levels of hypothalamic and serum OT between young and middle-aged perimenopausal female rats and examined the relationship between serum estrogen and leptin levels.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In perimenopausal rats, serum oxytocin levels did not correlate with hypothalamic oxytocin mRNA levels or serum E2 levels.

    In plain wordsIn rats, the body's own blood oxytocin did not track with brain oxytocin gene activity or with estradiol levels.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorrelation of serum oxytocin with hypothalamic oxytocin mRNA and serum E2
    Study

    ratn: not reported in source

    Young and middle-aged perimenopausal female rats
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Serum OT levels did not correlate with hypothalamic OT mRNA levels or serum E2 levels.
    1 context sentence
    Summary · context
    Therefore, we herein compared endogenous levels of hypothalamic and serum OT between young and middle-aged perimenopausal female rats and examined the relationship between serum estrogen and leptin levels.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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