Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies.

Pawłowska M, Marzec M, Jankowiak W, Nowak I

Life (Basel, Switzerland)24 Sept 2024Cited by 3 (Europe PMC)

PMID39459512PMCIDPMC11508827DOI10.3390/life14101212PepBankPUB-39459512

Summary

The use of lipid nanocarriers as components of cosmetic formulations may provide an opportunity to fully exploit the beneficial properties of pentapeptide-18 and retinol while reducing the undesirable effects that occur during retinoid therapy. This study aimed to evaluate the effectiveness of semi-solid formulations enriched with retinol and oligopeptide-loaded lipid nanocarriers. Solid lipid nanoparticles were produced using a high-shear homogenization method. The work included physicochemical characterization of the cosmetic products, and evaluation of their stability as well as their efficacy. The resulting semi-solid preparations were determined to be stable regardless of their storage temperature. No effect of the presence of lipid nanoparticles on the shelf-life stability of the cosmetic products was observed. A temperature of 25 °C was considered the recommended storage temperature for the tested semi-solid formulations. Beneficial effects of the cosmetic products were proven (in vivo study on volunteers), i.e., a significant reduction in the level of sebum secretion (anti-acne therapy) and a decrease in the number of facial wrinkles (anti-aging therapy). In addition, the protective properties of the lipid nanoparticles themselves against the skin were confirmed, reducing the irritating effect of retinol that is usually the case with classic retinoid therapies.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Pentapeptide-18 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Pentapeptide-18.

01HumanNot a test of Pentapeptide-18 aloneNon-randomized trialEfficacy outcome
In volunteers, formulations containing retinol and pentapeptide‑18 lipid nanocarriers significantly reduced sebum secretion.
In plain wordsIn volunteers, formulations with retinol and pentapeptide‑18 reduced skin oil secretion.
Peptide
Pentapeptide-18
Outcome
DecreaseSebum secretion
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Beneficial effects of the cosmetic products were proven (in vivo study on volunteers), i.e., a significant reduction in the level of sebum secretion (anti-acne therapy) and a decrease in the number of facial wrinkles (anti-aging therapy).
1 context sentence(design, population, supporting numbers)
Summary · context
This study aimed to evaluate the effectiveness of semi-solid formulations enriched with retinol and oligopeptide-loaded lipid nanocarriers.
In this study, Pentapeptide-18 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pentapeptide-18.
Show in the study text Report a problemFND-3945951201
02HumanNot a test of Pentapeptide-18 aloneNon-randomized trialEfficacy outcome
In volunteers, formulations containing retinol and pentapeptide‑18 lipid nanocarriers decreased facial wrinkle counts.
In plain wordsIn volunteers, formulations with retinol and pentapeptide‑18 reduced facial wrinkles.
Peptide
Pentapeptide-18
Outcome
DecreaseFacial wrinkle count
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Beneficial effects of the cosmetic products were proven (in vivo study on volunteers), i.e., a significant reduction in the level of sebum secretion (anti-acne therapy) and a decrease in the number of facial wrinkles (anti-aging therapy).
1 context sentence(design, population, supporting numbers)
Summary · context
This study aimed to evaluate the effectiveness of semi-solid formulations enriched with retinol and oligopeptide-loaded lipid nanocarriers.
In this study, Pentapeptide-18 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pentapeptide-18.
Show in the study text Report a problemFND-3945951202

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

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