The Relationship Between MOTS-c K14Q Polymorphism and Sarcopenia, Blood Lipids, and Mental Health in Older Korean Adults.

Kim S

Biomedicines18 Oct 2024Cited by 1 (Europe PMC)

PMID39457696PMCIDPMC11504729DOI10.3390/biomedicines12102384PepBankPUB-39457696

Summary

Background/objectives: An East Asian-specific 1382A>C polymorphism in the mitochondrial open reading frame of the 12S rRNA type-c results in an amino acid substitution from Lys (K) to Gln (Q) at the 14th amino acid residue. This study investigated the association between m.1382A>C polymorphism and sarcopenia, blood lipids, and mental health in older Korean adults. Methods: The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older. The m.1382A>C polymorphism was genotyped with a 7500 real-time PCR system. Handgrip strength (HGS) was measured, and appendicular skeletal muscle (ASM) mass was calculated. Demographics, blood lipids, falling risk, nutritional intake, cognition function, and depression were additionally measured. Results: Men carrying the C allele had significantly higher ASM (21.6 ± 3.0 vs. 19.5 ± 2.2 kg, p = 0.018), ASM/height² (7.76 ± 0.76 vs. 7.14 ± 0.62 kg/m², p = 0.012), lean mass (53.3 ± 6.2 vs. 46.5 ± 4.0 kg, p < 0.001), left HGS (33.3 ± 5.0 vs. 28.9 ± 4.0 kg, p = 0.010), and right HGS (35.6 ± 5.3 vs. 30.9 ± 4.3 kg, p = 0.009) than men carrying the A allele. The genotype differences in ASM (p = 0.017), ASM/height² (p = 0.011), lean mass (p p = 0.010), and right HGS (p = 0.009) remained significant even after adjusting for all measured covariates. By contrast, no significant differences in other measured parameters were found between women carrying the A and C alleles. Conclusions: Our study findings indicate that the m.1382A>C polymorphism may be used as a genetic biomarker of age-related sarcopenia in older Korean men.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MOTS-c.

01HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean men, carriers of the MOTS‑c m.1382A>C C allele had higher appendicular skeletal muscle mass than A allele carriers.
In plain wordsIn older Korean men, carrying the C version of a MOTS‑c gene variant was linked to more muscle mass than the A version.
Peptide
MOTS-c
Outcome
IncreaseAppendicular skeletal muscle mass by genotype in men
Study
n = 345
Comparator
Men carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
Men carrying the C allele had significantly higher ASM (21.6 ± 3.0 vs. 19.5 ± 2.2 kg, p = 0.018)
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769601
02HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean men, carriers of the C allele had higher height-adjusted appendicular skeletal muscle mass than A allele carriers.
In plain wordsIn older Korean men, carrying the C version of a MOTS‑c gene variant was linked to more height-adjusted muscle mass.
Peptide
MOTS-c
Outcome
IncreaseASM/height2 by genotype in men
Study
n = 345
Comparator
Men carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
ASM/height² (7.76 ± 0.76 vs. 7.14 ± 0.62 kg/m², p = 0.012)
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769602
03HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean men, carriers of the C allele had higher lean mass than A allele carriers.
In plain wordsIn older Korean men, carrying the C version of a MOTS‑c gene variant was linked to more lean mass.
Peptide
MOTS-c
Outcome
IncreaseLean mass by genotype in men
Study
n = 345
Comparator
Men carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
lean mass (53.3 ± 6.2 vs. 46.5 ± 4.0 kg, p < 0.001)
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769603
04HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean men, carriers of the C allele had higher left handgrip strength than A allele carriers.
In plain wordsIn older Korean men, carrying the C version of a MOTS‑c gene variant was linked to a stronger left hand grip.
Peptide
MOTS-c
Outcome
IncreaseLeft handgrip strength by genotype in men
Study
n = 345
Comparator
Men carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
left HGS (33.3 ± 5.0 vs. 28.9 ± 4.0 kg, p = 0.010)
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769604
05HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean men, carriers of the C allele had higher right handgrip strength than A allele carriers.
In plain wordsIn older Korean men, carrying the C version of a MOTS‑c gene variant was linked to a stronger right hand grip.
Peptide
MOTS-c
Outcome
IncreaseRight handgrip strength by genotype in men
Study
n = 345
Comparator
Men carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
right HGS (35.6 ± 5.3 vs. 30.9 ± 4.3 kg, p = 0.009)
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769605
06HumanNot a test of MOTS-c aloneObservational studyOther
In older Korean women, no significant differences in measured parameters were found between carriers of the A and C alleles.
In plain wordsIn older Korean women, a MOTS‑c gene variant was not linked to any measured difference.
Peptide
MOTS-c
Outcome
No significant changeMuscle, lipid and mental health measures by genotype in women
Study
n = 338
Comparator
Women carrying the A allele
Outcome group
Exercise and physical function · Musculoskeletal
Source sentences
Summary
By contrast, no significant differences in other measured parameters were found between women carrying the A and C alleles.
1 context sentence(design, population, supporting numbers)
Summary · context
The study included 683 community-dwelling Korean adults (345 men and 338 women) aged 65 years and older.
In this study, MOTS-c was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MOTS-c.
Show in the study text Report a problemFND-3945769606

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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