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Study · Not a test of the peptide alone · 2024

13 results

An Assessment of the Safety, Efficacy, and Tolerability of a Novel Scalp Treatment Regimen Combining a Hydroxy Acid-Based Scrub and Copper Tripeptide Serum in the Management of Seborrheic Dermatitis in Adults.

Patel MN, Patel N, Merja A, Patnaik S

Cureus24 Sept 2024Cited by 1 (Europe PMC)

PMID39449909 (opens in a new tab)PMCIDPMC11501000 (opens in a new tab)DOI10.7759/cureus.70108 (opens in a new tab)PepBankPUB-39449909
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Summary

Background and objective Scalp dandruff, a prevalent dermatological condition marked by flaking and itching, affects a large segment of the population. Sun exposure, genetics, and dryness, along with winter conditions, indoor heating, and hard water, all contribute to moisture loss and scalp imbalance. This study aimed to evaluate the safety, efficacy, and tolerability of a novel regimen combining a scalp scrub with hydroxy acid derivatives for exfoliation and dandruff removal, and a serum containing copper tripeptide-1, witch hazel (Hamamelis virginiana), hesperidin, hyaluronic acid, and pea protein (Pisum sativum) for hydration and scalp health. Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff. Ethical approval was granted by ACEAS - Independent Ethics Committee and all participants provided written consent. The study evaluated changes in Adherent Scalp Flaking Score (ASFS), scalp hydration with the Corneometer® CM 825, hair thickness, hair density, and scalp condition using CASLite Nova. Scalp appearance and treatment usage perception were evaluated on day 1, day 8, and day 15. Statistical analysis was conducted using SPSS Statistics v29.0.1.0 (IBM Corp., Armonk, NY) and Microsoft Excel 2019, with results reported as p-values and 95% confidence intervals (CI). Results As per the ASFS scale for adherent scalp flaking, a significant improvement of 61.24% (p<0.0001) was observed by day 15. Assessments with CASLite Nova showed significant increases in hair density and hair thickness by 12.48% (p<0.0001) and 25.36% (p<0.0001), respectively. Regarding scalp condition, the proportion of individuals with a dry scalp and significant keratin decreased from 65.52% at baseline to 6.9% by day 15. The incidence of dry scalp with fine dandruff also decreased from 6.9% at baseline to 0% by day 15. Conversely, the percentage of individuals with a dry scalp and some keratin increased from 27.59% at baseline to 48.28% by day 15. Also, the proportion of subjects with a normal scalp, characterized by good hair density and thickness, increased from 0% at baseline to 44.83% by day 15. Scalp skin hydration, measured by Corneometer® CM 825, showed a significant improvement of 76.24% (p<0.0001) from baseline to day 15. Overall, there were notable enhancements in scalp appearance, with reductions in itchiness, redness, roughness, and scaliness. All subjects reported satisfaction with the treatment. Conclusions The ThriveCo scalp regimen (scalp scrub + serum) has been demonstrated to be both effective and safe in treating and reducing scalp dandruff in healthy adults. The regimen significantly reduced ASFS by effectively removing visible scalp flakes from day 1 to day 15 with continuous use. Furthermore, the kit improved overall scalp condition, increased skin hydration, and enhanced the scalp's appearance. The components include scalp scrub with hydroxy acid derivatives for exfoliation and dandruff removal, and a serum containing copper tripeptide-1, Hamamelis virginiana, hesperidin, hyaluronic acid, and pea protein (Pisum sativum) for hydration and overall scalp health over the 15-day treatment period. The synergistic effects of this regimen work to clear visible dandruff flakes, reduce adherent scalp flaking, rejuvenate the scalp, and simultaneously strengthen the hair.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study13

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone13

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 01HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    In adults with mild to moderate dandruff, the scrub and copper tripeptide serum regimen improved the Adherent Scalp Flaking Score by 61.24% by day 15.

    In plain wordsIn adults with dandruff, a scrub plus copper tripeptide serum was linked to less scalp flaking by day 15.

    Peptide
    GHK-Cu
    Outcome
    DecreaseAdherent Scalp Flaking Score
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    ASFS improvement
    61.24%
    day 15

    Source sentences

    Summary
    Results As per the ASFS scale for adherent scalp flaking, a significant improvement of 61.24% (p<0.0001) was observed by day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 02HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    In adults using the scrub and copper tripeptide serum regimen, hair density increased by 12.48%.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, hair density was higher.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHair density
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Hair density increase
    12.48%
    day 15

    Source sentences

    Summary
    Assessments with CASLite Nova showed significant increases in hair density and hair thickness by 12.48% (p<0.0001) and 25.36% (p<0.0001), respectively.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  3. 03HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    In adults using the scrub and copper tripeptide serum regimen, hair thickness increased by 25.36%.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, hair thickness was higher.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHair thickness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Hair thickness increase
    25.36%
    day 15

    Source sentences

    Summary
    Assessments with CASLite Nova showed significant increases in hair density and hair thickness by 12.48% (p<0.0001) and 25.36% (p<0.0001), respectively.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  4. 04HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The proportion of individuals with a dry scalp and significant keratin decreased from 65.52% at baseline to 6.9% by day 15.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, fewer people had a dry scalp with much keratin by day 15.

    Peptide
    GHK-Cu
    Outcome
    DecreaseDry scalp with significant keratin
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Proportion
    65.52%
    baseline
    Proportion
    6.9%
    day 15

    Source sentences

    Summary
    Regarding scalp condition, the proportion of individuals with a dry scalp and significant keratin decreased from 65.52% at baseline to 6.9% by day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  5. 05HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The incidence of dry scalp with fine dandruff decreased from 6.9% at baseline to 0% by day 15.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, dry scalp with fine dandruff fell to none by day 15.

    Peptide
    GHK-Cu
    Outcome
    DecreaseDry scalp with fine dandruff
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Incidence
    6.9%
    baseline
    Incidence
    0%
    day 15

    Source sentences

    Summary
    The incidence of dry scalp with fine dandruff also decreased from 6.9% at baseline to 0% by day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  6. 06HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The percentage of individuals with a dry scalp and some keratin increased from 27.59% at baseline to 48.28% by day 15.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, more people had a dry scalp with some keratin by day 15.

    Peptide
    GHK-Cu
    Outcome
    IncreaseDry scalp with some keratin
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Proportion
    27.59%
    baseline
    Proportion
    48.28%
    day 15

    Source sentences

    Summary
    Conversely, the percentage of individuals with a dry scalp and some keratin increased from 27.59% at baseline to 48.28% by day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  7. 07HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The proportion of subjects with a normal scalp increased from 0% at baseline to 44.83% by day 15.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, more people had a normal scalp by day 15.

    Peptide
    GHK-Cu
    Outcome
    IncreaseNormal scalp with good hair density and thickness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Proportion
    0%
    baseline
    Proportion
    44.83%
    day 15

    Source sentences

    Summary
    Also, the proportion of subjects with a normal scalp, characterized by good hair density and thickness, increased from 0% at baseline to 44.83% by day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  8. 08HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    Scalp skin hydration improved by 76.24% from baseline to day 15.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, scalp hydration was higher by day 15.

    Peptide
    GHK-Cu
    Outcome
    IncreaseScalp skin hydration (Corneometer)
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Measurements

    Hydration improvement
    76.24%
    day 15

    Source sentences

    Summary
    Scalp skin hydration, measured by Corneometer® CM 825, showed a significant improvement of 76.24% (p<0.0001) from baseline to day 15.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  9. 09HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The regimen was followed by reductions in scalp itchiness.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, scalp itchiness was lower.

    Peptide
    GHK-Cu
    Outcome
    DecreaseScalp itchiness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overall, there were notable enhancements in scalp appearance, with reductions in itchiness, redness, roughness, and scaliness.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  10. 10HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The regimen was followed by reductions in scalp redness.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, scalp redness was lower.

    Peptide
    GHK-Cu
    Outcome
    DecreaseScalp redness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overall, there were notable enhancements in scalp appearance, with reductions in itchiness, redness, roughness, and scaliness.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  11. 11HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The regimen was followed by reductions in scalp roughness.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, scalp roughness was lower.

    Peptide
    GHK-Cu
    Outcome
    DecreaseScalp roughness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overall, there were notable enhancements in scalp appearance, with reductions in itchiness, redness, roughness, and scaliness.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  12. 12HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    The regimen was followed by reductions in scalp scaliness.

    In plain wordsIn adults using a scrub plus copper tripeptide serum, scalp scaliness was lower.

    Peptide
    GHK-Cu
    Outcome
    DecreaseScalp scaliness
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    Overall, there were notable enhancements in scalp appearance, with reductions in itchiness, redness, roughness, and scaliness.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  13. 13HumanNot a test of GHK-Cu aloneNon-randomized trialEfficacy outcome

    All subjects reported satisfaction with the scrub and copper tripeptide serum regimen.

    In plain wordsAll adults in the study reported satisfaction with the scrub plus copper tripeptide serum.

    Peptide
    GHK-Cu
    Outcome
    Not applicableParticipant satisfaction
    Study

    n: not reported in source

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    All subjects reported satisfaction with the treatment.
    1 context sentence
    Summary · context
    Methods This prospective, interventional, open-label, single-center study assessed the safety, efficacy, and in-use tolerability of a scalp scrub and serum regimen for mild to moderate dandruff.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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