Skip to content

Study · Animal study (in vivo) · mouse · 2024

2 results

Ghrelin is essential for lowering blood pressure during torpor.

Matsui K, Ida T, Oishi K, Kojima M, Sato T

Frontiers in endocrinology10 Oct 2024Cited by 2 (Europe PMC)

PMID39449746 (opens in a new tab)PMCIDPMC11499174 (opens in a new tab)DOI10.3389/fendo.2024.1487028 (opens in a new tab)PepBankPUB-39449746
Download PDFPubMedAsk about this study
Jump to 2 results

Summary

IntroductionDaily torpor is an active hypothermic phenomenon that is observed in some mammals and birds during fasting. A decrease in blood pressure has also been observed in torpor; however, there remains a lack of knowledge of the underlying mechanism. We have previously reported that ghrelin, an orexigenic hormone, has a hypothermic effect and is essential for the induction and maintenance of torpor. It is also known that the ghrelin secretion is enhanced during fasting and that ghrelin receptors are distributed in the cardiovascular system. Therefore, this study was conducted to test the hypothesis that ghrelin is actively involved in the regulation of blood pressure during torpor induction.MethodsMale wild-type and ghrelin gene-deficient mice were generated by homologous recombination as previously reported. Mice, 10 weeks old, were included in this study and housed five per cage. The mice were maintained on a 12-h light/dark cycle (lights on from 7:00 to 19:00) with access to food and water ad libitum.ResultsThe continuous measurement of blood pressure using a telemetry system showed that induction of torpor by fasting did not decrease blood pressure in ghrelin gene-deficient mice. The analysis of heart rate variability revealed that sympathetic nerve activity was predominant in ghrelin-deficient mice during fasting. Furthermore, these features were cancelled by administration of a ghrelin receptor agonist and were comparable to those in wild-type mice.DiscussionIn this study, we showed that blood pressure was elevated in ghrl-/- mice and that the blood pressure rhythm was abnormal. Furthermore, we showed that the ghrelin gene deficiency does not cause sufficient blood pressure reduction upon entry into the torpor, and that the administration of the ghrelin receptor agonist, GHRP-6, causes blood pressure reduction associated with torpor. Thus, we have shown for the first time that the active role of ghrelin is essential for active blood pressure reduction associated with torpor, and that this action is mediated by the inhibition of sympathetic nerve activity by ghrelin.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In fasting ghrelin-deficient mice, GHRP‑6 restored blood pressure reduction associated with torpor to a pattern comparable with wild-type mice.

    In plain wordsIn fasting ghrelin-deficient mice, GHRP‑6 restored the blood pressure decrease seen in wild-type mice during torpor.

    Peptide
    GHRP-6
    Outcome
    DecreaseBlood pressure during torpor
    Study

    mousen: not reported in source

    Ghrelin gene-deficient mice during fasting
    Comparator
    Ghrelin gene-deficient mice without agonist
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, these features were cancelled by administration of a ghrelin receptor agonist and were comparable to those in wild-type mice.
    4 context sentences
    Summary · context
    The continuous measurement of blood pressure using a telemetry system showed that induction of torpor by fasting did not decrease blood pressure in ghrelin gene-deficient mice.
    Summary · context
    Furthermore, we showed that the ghrelin gene deficiency does not cause sufficient blood pressure reduction upon entry into the torpor, and that the administration of the ghrelin receptor agonist, GHRP-6, causes blood pressure reduction associated with torpor.
    Summary · context
    Male wild-type and ghrelin gene-deficient mice were generated by homologous recombination as previously reported.
    Summary · context
    Mice, 10 weeks old, were included in this study and housed five per cage.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In fasting ghrelin-deficient mice, the ghrelin receptor agonist reversed sympathetic activity predominance, producing features comparable with wild-type mice.

    In plain wordsIn fasting ghrelin-deficient mice, the receptor agonist reversed sympathetic activity predominance toward the pattern in wild-type mice.

    Peptide
    GHRP-6
    Outcome
    DecreaseSympathetic nerve activity predominance
    Study

    mousen: not reported in source

    Ghrelin gene-deficient mice during fasting
    Comparator
    Ghrelin gene-deficient mice without agonist
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, these features were cancelled by administration of a ghrelin receptor agonist and were comparable to those in wild-type mice.
    4 context sentences
    Summary · context
    The analysis of heart rate variability revealed that sympathetic nerve activity was predominant in ghrelin-deficient mice during fasting.
    Summary · context
    Furthermore, we showed that the ghrelin gene deficiency does not cause sufficient blood pressure reduction upon entry into the torpor, and that the administration of the ghrelin receptor agonist, GHRP-6, causes blood pressure reduction associated with torpor.
    Summary · context
    Male wild-type and ghrelin gene-deficient mice were generated by homologous recombination as previously reported.
    Summary · context
    Mice, 10 weeks old, were included in this study and housed five per cage.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.