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Study · Observational study · n = 66 · 2024

6 results

Safety and efficacy of enclomiphene and clomiphene for hypogonadal men.

Saffati G, Kassab J, Orozco Rendon D, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, Khera M

Translational andrology and urology24 Sept 2024Cited by 5 (Europe PMC)

PMID39434750 (opens in a new tab)PMCIDPMC11491226 (opens in a new tab)DOI10.21037/tau-24-238 (opens in a new tab)PepBankPUB-39434750
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In hypogonadal men, testosterone increases did not differ significantly between enclomiphene and clomiphene.

    In plain wordsIn hypogonadal men, testosterone increases did not differ significantly between enclomiphene and clomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeTestosterone change
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Median testosterone increase
    166 ng/dL
    enclomiphene
    Median testosterone increase
    98 ng/dL
    clomiphene

    Source sentences

    Summary
    Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (vs. 98 ng/dL, P=0.20) with lower estradiol change than clomiphene (-5.92 vs. 17.50 pg/mL, P=0.001).
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.
  2. 02HumanObservational studyEfficacy outcome

    In hypogonadal men, enclomiphene was associated with lower estradiol change than clomiphene.

    In plain wordsIn hypogonadal men, enclomiphene was linked to lower estradiol change than clomiphene.

    Peptide
    Enclomiphene
    Outcome
    DecreaseEstradiol change
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Estradiol change
    −5.92 pg/mL
    enclomiphene
    Estradiol change
    17.5 pg/mL
    clomiphene

    Source sentences

    Summary
    Among 66 patients, enclomiphene exhibited a median testosterone increase of 166 (vs. 98 ng/dL, P=0.20) with lower estradiol change than clomiphene (-5.92 vs. 17.50 pg/mL, P=0.001).
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.
  3. 03HumanObservational studySafety outcome

    In hypogonadal men, decreased libido was less frequent with enclomiphene than clomiphene.

    In plain wordsIn hypogonadal men, enclomiphene was linked to less frequent decreased libido than clomiphene.

    Peptide
    Enclomiphene
    Outcome
    DecreaseDecreased libido
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03).
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.
  4. 04HumanObservational studySafety outcome

    In hypogonadal men, reduced energy was less frequent with enclomiphene than clomiphene.

    In plain wordsIn hypogonadal men, enclomiphene was linked to less frequent reduced energy than clomiphene.

    Peptide
    Enclomiphene
    Outcome
    DecreaseReduced energy
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03).
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.
  5. 05HumanObservational studySafety outcome

    In hypogonadal men, mood changes were less frequent with enclomiphene than clomiphene.

    In plain wordsIn hypogonadal men, enclomiphene was linked to fewer mood changes than clomiphene.

    Peptide
    Enclomiphene
    Outcome
    DecreaseMood changes
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Adverse events · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Adverse effects were statistically significantly less frequent with enclomiphene, including decreased libido (P=0.001), reduced energy (P=0.044), and mood changes (P=0.03).
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.
  6. 06HumanObservational studySafety outcome

    In hypogonadal men, enclomiphene was associated with lower adverse event odds than clomiphene.

    In plain wordsIn hypogonadal men, enclomiphene was linked to lower odds of adverse events than clomiphene.

    Peptide
    Enclomiphene
    Outcome
    DecreaseAdverse event odds
    Study

    n = 66

    Comparator
    Clomiphene
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Measurements

    Odds ratio
    0.18 ratio
    enclomiphene versus clomiphene
    Odds ratio 95% CI
    0.07 to 0.44 ratio
    enclomiphene versus clomiphene

    Source sentences

    Summary
    Regression analysis confirmed lower odds of adverse events with enclomiphene [OR: 0.18; 95% confidence interval (CI): 0.07-0.44, P=0.02].
    2 context sentences
    Summary · context
    We retrospectively studied patients at our academic center who had been prescribed clomiphene and, later, enclomiphene for hypogonadism.
    Summary · context
    The same process was repeated for enclomiphene, using the clomiphene levels as an updated baseline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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