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Study · Animal study (in vivo) · rat · 2024

2 results

Changes of Transcriptomic Activity in Rat Brain Cells under the Influence of Synthetic Adrenocorticotropic Hormone-Like Peptides.

Filippenkov IB, Glazova NY, Sebentsova EA, Stavchansky VV, Andreeva LA, Myasoedov NF, Levitskaya NG, Limborska SA, Dergunova LV

Biochemistry. Biokhimiia1 Sept 2024

PMID39418522 (opens in a new tab)DOI10.1134/s0006297924090104 (opens in a new tab)PepBankPUB-39418522
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, Semax changed the expression of 258 genes in the frontal cortex versus saline (fold change above 1.5, adjusted P below 0.05).

    In plain wordsIn rats, Semax changed the activity of 258 genes in the front part of the brain cortex compared with saline.

    Peptide
    Semax
    Outcome
    MixedDifferentially expressed genes in frontal cortex
    Study

    ratn: not reported in source

    frontal cortex, normal physiological conditions
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Measurements

    Differentially expressed genes
    258 genes
    Semax versus saline, 22.5 h after first administration

    Source sentences

    Summary
    We identified 258 and 228 DEGs, respectively, with the fold change > 1.5 and Padj < 0.05 at 22.5 h after the first administration of Semax and ACTH(6-9)PGP.
    1 context sentence
    Summary · context
    Here, we used high-throughput RNA sequencing (RNA-Seq) to identify differentially expressed genes (DEGs) in the brain frontal cortex of rat receiving intraperitoneal administration of ACTH-like peptides ACTH(4-7)PGP (Semax) and ACTH(6-9)PGP, or saline.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, Semax predominantly decreased the expression of immune system genes in the frontal cortex.

    In plain wordsIn rats, Semax mostly lowered the activity of immune system genes in the front part of the brain cortex.

    Peptide
    Semax
    Outcome
    DecreaseExpression of immune system genes
    Study

    ratn: not reported in source

    frontal cortex, normal physiological conditions
    Comparator
    Saline
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Both peptides predominantly caused decrease in expression of the genes associated with the immune system.
    1 context sentence
    Summary · context
    Here, we used high-throughput RNA sequencing (RNA-Seq) to identify differentially expressed genes (DEGs) in the brain frontal cortex of rat receiving intraperitoneal administration of ACTH-like peptides ACTH(4-7)PGP (Semax) and ACTH(6-9)PGP, or saline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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